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Literature review Reducing the rate of SSBs consumption
Literature review: Reducing the rate of SSBs consumption
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Table of Contents
TOC o “1-3” h z u HYPERLINK l “_Toc372980768” 1.Introduction PAGEREF _Toc372980768 h 3
HYPERLINK l “_Toc372980769” 2.History of sugar sweeteners PAGEREF _Toc372980769 h 3
HYPERLINK l “_Toc372980770” 3.Sugar-sweetened beverages in America PAGEREF _Toc372980770 h 4
HYPERLINK l “_Toc372980771” 4.Correlation between sugar-sweetened beverages and obesity PAGEREF _Toc372980771 h 6
HYPERLINK l “_Toc372980772” 5.Reducing the rate of SSBs consumption PAGEREF _Toc372980772 h 7
HYPERLINK l “_Toc372980773” 5.1 Moderate taxation of sugar sweetened beverages PAGEREF _Toc372980773 h 8
HYPERLINK l “_Toc372980774” 5.2 Extreme tax on SSBs PAGEREF _Toc372980774 h 9
HYPERLINK l “_Toc372980775” 6.Media influence in SBBs consumption PAGEREF _Toc372980775 h 10
HYPERLINK l “_Toc372980776” 7.Banning of SSBs in schools PAGEREF _Toc372980776 h 14
HYPERLINK l “_Toc372980777” 8.Participation of beverage manufacturers PAGEREF _Toc372980777 h 14
HYPERLINK l “_Toc372980778” 9.Conclusion PAGEREF _Toc372980778 h 15
Introduction
The available statistics on consumption of caloric sweeteners indicates that between 1977 and 19996, the consumption of SSBs increased by 22% while between 1994 and 1996 the consumption increased by 30% (John & Chad, 2012). Currently, the most common source of the added sugar is non-diet soft drinks which account for half of the total added sugars in the American diet. Soft drink includes products as fruit drinks, lemonade and iced tea. Beside soft drinks, consumption of fruit drinks and fruitades are equally common especially in children and young children. The literature review focuses on the potential that can be used to reduce the rate of SSBs consumption, in the American context.
History of sugar sweetenersAccording to Apovian (2004) sugar derived from sugar cane was first developed in India and New Guinea and then the concept spread to Europe and Americas. Sugarcane was brought to the Americas and the Caribbean Islands by the Christopher Columbus. At the time, sugar was a very precious commodity, but afterwards mass production, increased its availability to the public. Today, sugar is a common ingredient in foods and drinks. Before introduction of sugar in diet, people normally depended on starch-based alternatives such as barley, wheat, oats, and rye. High-fructose corn syrup was introduced in the American market in 1970s and is preferred to normal sugar due to its long shelf life and is used in soft drinks, fruit punches, pastries and processed foods. According to Apovian (2004) both sugar and high fructose corn syrup have increased calories intake among the Americans population by 30% over the pat 40 years. With increased consumption of sugar, researchers have started becoming wary of its effects on peoples’ lives.
Sugar-sweetened beverages in AmericaSugar-sweetened beverages (SSBs) contain added sugar, high-fructose corn syrup and caloric sweeteners. They have become prevalent in America, where they are found to provide the general population with empty-calories besides being a major contributor to the current obesity epidemic. According to Babey, Wolstein and Goldstein (2013) for the pasts 50 years consumption of Sugar Sweetened Beverage has increased by 500% and the rate of consumption of SSBs in children is higher than that of milk. The available statistics suggest that SSBs account for 10-15% of total daily calories in children. Given the negative effects of Sugar Sweetened Beverage in children past efforts have bee taken by organizations such as the American Heart Association and Clinton Foundation to remove sweetened products in schools and replacing them with lower-calorie drinks.
Looking globally, the consumption of SSBs has been on the rise. In Mexico, the rise in the consumption of the SBBs has forced the government to take serious interventions while in China, India, Vietnam, and South Asian countries positive consumption trajectories have been reported. Incidences of obesity vary according to many factors including age, gender, education, and geographic distribution. In this regard, obesity menace is likely to affect elderly patients and thus consumption of sugar-sweetened beverages for members of this group should be discouraged. On the other hand, women have higher obesity rates than men. This means that adults, especially women should limit their daily SSBs consumption because they are more likely to gain weight than men. The level of family income also determines the level of SSBs consumption and ultimately the risk of obesity. In this regard, person from poor backgrounds are more predisposed to using sugar-sweetened beverages and hence are more susceptible to becoming overweight and obese. Babey, wolstein and Goldstein (2013) attribute this outcome to the fact that persons from poor backgrounds have low education and food knowledge, compared to their counterparts from high income families.
The available literature has investigated the prevalence of SSBs consumption in the society. Data released by the World Health Organization indicates that more one billion adults are overweight with a BMI of more ≥25 while 300 million people are obese with a BMI of ≥ 30. In the U.S. about 130 million are obese, and indication that the country accounts for a huge proportion of obesity cases in the world. These trends are worrying given that obesity is associated with negative outcomes such as hypertension, cardiovascular diseases, diabetes, prostrate cancer and depression. A study conducted by Ogden and Carrol (proposal) indicates that in America is obese and suggests that increased consumption of SSBs is likely to increase the already high obesity rates. The high levels of obesity in the country negatively impacts on the resources available. Already, the U.S. government spends more than $147 billion for the treatment of obesity-related ailments and this account for almost 10% of the total health care expenditure. At the same time, obesity is associated with lost of productivity costs. This ie because obese employees are more likely to miss work more that health works due to health-related problems and work for less hours. The employers are affected by the obesity menace as they are forced to pay higher in premium for employees diagnosed with obesity. A recent study conducted by John and Chad (2012) provides us with worrying statistics which illustrate the gravity of the obesity menace. According to John and Chad (2012) obesity-related ailments account for a fifth of the national health expenditures and while another one conducted by Rappange, Brouwer, Hoogenveen and Baal (2009) suggest that life-time drug expenditures for the obese persons is higher than for the healthy ones. This comprehensive study further concluded that obesity prevention significantly reduces drug expenditures and this one of the ways in which the government can be able to reduce the increasing health-care expenditure.
Correlation between sugar-sweetened beverages and obesityThere are many studies that have examined the associations between consumption of SSBs and risk of diabetes. Schulze et al. (2004) used a sample of 116,671 women aged between 22-44 to examine the relation between SSBs consumption and weight change. Follow up studies were carried out between 1991 and 1999, and Schulze et al. (2004) concluded that there is a positive relation between SSBs consumption and weight gain and incidences of obesity. On the other hand, Vasanti, Mathias and Fran (2007) conducted a systematic review to investigate the effects of SSBs consumption on the health of the consumers. The systematic review included fifteen cross-sectional studies, all of which confirmed the positive association between consumption of SSBs and body weight gain, and risk of obesity. The studies involved in this systematic review all had strong methodologies and underwent a strict selection criterion. In addition, all the studies have large sample population, thus allowing the researchers to obtain conclusive evidence. The effects of the SSBs are also captured in a study by Dubois, Framer, Girard and Peterson (2007). In the study, a sample population of 1,944 schools going children was used and the data was collected through qualitative methods and then a multivariate regression analysis was conducted. As expected, the study conduced that regular SSBs consumption puts young children at a higher risk for obesity. The study challenge parents to limit the number of SSBs they give to their children. Research evidence for reducing SSBs in children is again given by Bellisle and Drewnowski (2007) in a study who sample population was aged between 2 and 5 years. Bellisle and Drewnowski (2007) evaluated the longitudinal and cross-sectional relationships between SSBs consumption and weight gain and found out children in this age bracket should decrease SSBs consumption for healthy living.
While the available studies have established a positive association between SSBs consumption and obesity, a few have examined the biological mechanisms leading to weigh gain. Bellisle and Drewnowski (2007) believe that SSBs lead to decreased satiety and incomplete compensatory reduction in energy intake in the subsequent meals. On the other hand, sucrose, and high-fructose corn syrups, lead to high dietary glacemic load and hence a higher risk for diabetes mellitus type 2 and cardiovascular diseases. The available literature has also found out that SSBs promotes accumulation of intra-abdominal adiposity and other unintended consequences. To prevent the high risk for obesity, the American Hearty Association recommends a daily intake of 100-5150 kcal and other alternatives such as consumption of water. Beside obesity, consumption sugar-sweetened beverages are associated with multiple obesity-related co morbidities such as hypertension, and cardiovascular diastase. Experts believe that increased calorie intake, not only leads to hypertension and also stroke, heart failure and myocardial infraction.
Reducing the rate of SSBs consumptionIt is apparent that there is strong epidemiologic and clinical evidence linking SSBs and increased risk of obesity and obesity-related co-morbidities. From the above section, it is also apparent that there is need to provide school children with proper diet with low calories. This fact is exemplified by Babey, wolstein and Goldtsein (2013) in an article titled, still bubbling: California adolescents drinking more soda and other sugar-sweetened beverages. In this study, which was conducted in California, Babey, wolstein and Goldstein (2013 found out that consumption of SSBs in adolescents and children is still unacceptably high and SSBs are inferior compared to solid foods because they are associated with decreased intake of nutritious and more healthy foods. The study further found out that social and environmental factors are contributing to the increased consumption of SSBs. The article offers helpful suggestions such as educating children and parents about the health effects of SSBs. Despite these findings, it is apparent that there is limited literature on the interventions that can be used to reduce the higher obesity rates. This literature review, seeks to feel gaps by critically examining some of the potential measures that could prove helpful.
5.1 Moderate taxation of sugar sweetened beveragesBrownell et al. (2009) gives us irrefutable evidence on the adverse effects of sugar-sweetened beverages and then goes ahead to propose a tax system that could promote good nutrition and the national government to recover the additional healthcare costs associated with their consumption. According to Brownwell et al. (2009) an appropriate tax system has a potential of reducing the intake of beverages and this conclusion is based on the fact that changes in relative prices of foods and beverages will lead to changes in how much people consume. In this regard, Brownell et al. (2009) observes that a 10% increase in prices of sugar-sweetened beverages will translate to a 11% reduction in the consumption rate while Apovian (2004) argues that a 10% increase in the price of fast food, is associated with a 6% reduction in adolescent obesity. At the same time, researchers have established that an increase in SSB prices could increase consumption of healthier beverages such as milk and tea. Ultimately, increased consumption of healthier diets will reduce the prevalence of overweight among adults and children.
At the moment, most of the states only levy a sales tax on SSBs products and this situation can be improved on by placing an excise tax of 1% per ounce for beverages. Alternatively as Brownell et al. (2009) suggests the government could levy an excise tax on SSBs that exceed a threshold of grams of added caloric sweetener. The extra revenue generated could then be used to run obesity-prevention programs. While this idea could be appropriate, it could be prove inadequate as obesity-related prevention programs should be multipronged rather than increasing taxes on SSBs only.
Although research indicates that modest taxation on SSBs products could lead to a reduction in obesity levels, some studies tend to differ. A study by Powell, Chriqui, and Chaloupka (2009) found no association between modest taxes and adolescent weight outcomes. Just to illustrate this point, it is well acknowledged that in most states, SSBs attract higher sales tax, than other food products at 5.2%. However, despite this higher tax relative to other products in the same category, the level of consumption of SSBs is still high. The results of this study are reinforced by Kim (2009) who argues that modest taxes may not be result in a relative change in SSBs consumption. The results of these two studies, suggests that the government the needs to use stricter tax regimes in order to achieve tangible results as far as reduction of obesity in the society is concerned.
5.2 Extreme tax on SSBsThe limited research available shows that moderate taxation may not be effective in obesity prevention. These findings suggest that maybe states and government should consider levying extremely high taxes, either through excise tax to increase sales tax. The effectiveness of such a strategy is discussed in an article titled, 20% tax on sugary drinks would help cut obesity researchers say. In this article, medical researchers from the Academy of Medical Royal Colleges support a high tax on coca-cola, Pepsi, Fanta and other sugar-sweetened products. While supporting this move, researchers associate the 20% tax increase with a 1 % reduction in obesity cases. Those who are most likely to benefit from this strategy are those aged between 16 and29 while the government would be able to realize higher revenue. The additional revenue would be used to subsidize the prices of nutritional foods such as fruits and vegetable. Already countries such as Hungary, Finland and France have introduced high taxes on SSBs. While the information contained in this article is important, the information it contains is not supported by hard data.
It seems the proposal to levy SSBs high taxes is not supported by manufacturers as they would loose profitability due to high customer churn rate. To examine the likely impact of charging high taxes rather than modest prices, Maria et al. (2013) conducted a systematic review. In the study, Maria et al. (2013) used research articles from credible databases published between January 2000 and January 2013. Majority of the articles satisfied the selection criteria and showed that higher taxes on SSBs would translate to a decrease in BMI and the prevalence of overweight and obesity.
The effectiveness of high taxation on SSBs is revisited in an article titled, taxation prevention and as a treatment for obesity: the case of sugar-sweetened beverages. The article supports the introduction of high taxes on nutrient-poor products in order to nudge the customers towards healthier feeds. Novak and Brownell (2011) are disappointed that currently, the level of taxation on SSBs is very low, to affect consumer behavior. According to Novak and Brownell (2011) tax reduction of 20% would lead to an average weight reduction of 3.8 pounds per year for adults. In addition, this level of taxation would result in a 30% to 33% reduction of obesity incidences in the country. From these results, it is apparent that the obesity epidemic in the country can only be resolved through introduction of high taxes and not moderate taxes. However, the strategy is unlikely to work due to the stiff opposition from the players in the beverage industry.
Media influence in SBBs consumptionOne of the powerful tools that have been used to market the SBBs is the media. The importance of the media to businesses is well investigated by Berger (2004). Advertising is an important part of the American society and is a useful tool in portraying a particular attribute about a product or a service. Whether print or non-print, advertisements are supposed to attract consumers within a particular segment, and then stimulate action that results in the actual purchase of products and services being advertised. SSBs manufacturers will go to any extent to sell their products and services. As of now, consumers are becoming increasingly careful of what they eat, and some of the manufacturers are advertising their products to be healthy while they are not. This whole issue is related to the concept of branding and the use of marketing mix elements, which are important in conveying the right information to the buyers to help them make healthier food choices. According to Chrysochou (2010) most of the media tools that are used during branding of foods are primary communication channels and secondary channels. At the same time, the manufacturers use innovative strategies such as celebrity endorsements to endear their products to the consumers.
One of fundamental questions concerning the consumption of the SSBs is why consumers continue using the products, knowing too well their harmful effects. The answer to this question can be found in the article titled, communication on food, health and nutrition. According to Gram, De la Ville, Le Roux, Boireau and Rampnoux (2010) the beverage industry uses a lot resource in marketing their products. One of the common strategies used by the large companies such Coca-Cola is differentiation of their products. Currently, the company offers a wide range of products to suit the needs of different customers’ needs. The company has sizable market share in the fruit drinks, energy drinks, sports drinks, iced tea and vitamin-enriched water markets.
To increase the penetration of their products, the players in the food industry depends on the market segmentation. Through micro-segmentation they are able to fulfill particular characteristics of the target population and according to Gram, De la Ville, Le Roux, Boireau and Rampnoux (2010) the young population is segmented by gender, lifestyles and values. The other concept, as discussed by Gram, De la Ville, Le Roux, Boireau and Rampnoux (2010) is the use marketing positioning concept which allows consumers to identify products or bands. The players in the beverage industry depend on the functional and symbolic dimensions to sell different products and services to their wide clientele. The symbolic dimension is particularly important among the young people as they are sensitive to particular characteristics and values unlike the consumers in the other age groups. The marketing mix used by the beverages industries vary according to the type of the product being sold. In this regard, the soft drinks market targets the young consumers and to increase the consumption of products and service in this segment, the players in the food industry use multi-platform marketing. Likewise, energy drinks target the young population, and to increase their consumption, the food industry primarily uses the celebrity endorsement strategy. To promote the consumption of the soft drinks beverage manufacturers uses the similar strategy of celebrity endorsements.
While media can be used to popularize the use of SSBs it can also be used to influence good consumer choices. The effectiveness of the media in the reduction of SSBs consumption is well discussed in the article titled, developing media interventions to reduce household sugar-sweetened beverage consumption. In this article Jordan, Piotrowski, Bleakley and Mallya (2012) used a sample drawn from Philadelphia and the researchers used an integrative model to determine the most cost-effective message content. Jordan, Piotrowski, Bleakley and Mallya (2012) determined that effective messages should highlight concerns such as child weight gain in order to increase the intention to reduce SSBs.
Beside the use of mainstream media, studies have investigated whether social media could be used in the promotion of health behaviors in children and school going children. It is well acknowledged that consumers have huge access to the internet and social media tools and these social networks can be used to disseminate information to the most affected persons in the society. The results of 8 randomized trials support the use of internet-base interventions especially among children and adolescents who are heavy consumers of SSBs. The results of these studies indicate that social interventions can effectively be used to promote positive behaviors such as weight loss, reduction of the BMI, physical activity and natural diet intake. However, these studies used small samples, and the length of follow-ups was short hence the need to conduct further research using larger samples.
An alternative to using social media tools would be to regulate initiate federal regulations to limit consumption of SSBs. Only recently, the Council of the Better Business Bureau established guidelines to direct child-related advertisements. The use of federal regulation to regulate children-related advertisements is reinforced by Wiecha, Peterson, Ludwig, Kim, Sobol, and Gortmaker (2006) in a study conducted among 6th and 7th grade studies. According to Wiecha, Peterson, Ludwig, Kim, Sobol, and Gortmaker (2006) high rates of TV viewing translates to higher total calories, while low rates of TV viewing leads to lower total calories intake among the adolescents. The other available research on this issue concur that television marketing influences the short-term consumption of children aged between 2 and 11 years. Wiecha, Peterson, Ludwig, Kim, Sobol, and Gortmaker (2006) proposed a model to examine the likely effect if SSBs advertisements were banned, and found out that it would reduce prevalence of obesity by 2% and BMI by 0.38 kg/m2. Based on these results, some of the schools have taken deliberate measures to limit TV exposure to children and a good example is the State of Maine School Advertising Policy which prohibits brand-specific advertising in school building. Likewise in San Francisco, the Commercial Free School Act prohibits adverting of commercial products including SSBs within San Francisco Unified School District.
Banning of SSBs in schoolsFor long, school children have had unfettered access to SSBs but for the past few years some states and school districts have initiated policies to restrict these younger users. However, while such policies could limit access to SSBs they do not reduce their consumption. These findings are supported by a study performed by researchers led by Taber, Chriqui, Powell, and Chaloupka (2012). In this study, 6,900 students were surveyed in 40 different states and concluded state and school police are not associated with a reduction in consumption sweetened beverages (Taber, Chriqui, Powell, & Chaloupka, 2012). The results of these finding suggest that maybe schools and the authorities should rather use education programs to inform potential consumers about the negative effects of the SSBs. The effects of the school education programs are well documented in the study by James, Thomas, Cavan and Kerr (2004). In the study, use of school education programs led to a significant decrease in SSBs consumption and other positive outcomes. These results are replicated in a different study performed in sample drawn from the Midwestern families. Use of public education programs was found to increase consumption of health foods while reducing consumption of SSBs (Lawrence, Boyle, Craypo, & Samuels, 2009).
Participation of beverage manufacturersWhile the available literature has focused on the role of the media and taxation, in the reduction of SSBs consumption, few studies have investigated the potential role of the food industry in reducing consumption of unhealthy drinks especially among the youths and the adolescents. Despite the health concerns resulting from the use of SSBs, companies in the food industry have not take sincere steps to promote healthy behaviors among the consumers. Lack of commitment from the SSBs raises the issue of whether they can be able to cut calories in their products while maintaining profits. This issue is revisited by Kleiman and Popkin (2012) where they observe that some of the 16 biggest food and beverage companies in America have come together with the goal of reducing the number of calories consumed by the Americans. This partnerships, is intended to cut down calories consumption by 1.5 trillion by 2015. As Kleiman and Popkin (2012) observes, as a result of this initiative, positive effects are already being experienced, but more empirical studies need to be conducted to investigate the validity of these results.
ConclusionFor the past few decades the consumption of sugar-sweetened beverages has increased considerably and is one of the major contributors to the current obesity epidemic. The intake of sugary diet has also been linked to obesity-related co-morbidities such as hypertension, stroke, heart failure and myocardial infraction. Due to the strong epidemiologic and clinical evidence linking SSBs with adverse health outcomes, the available research has proposed introduction of higher taxes or decreasing the relative costs of more healthful beverage alternatives. The available literature seems to suggest that higher taxation is more effective than moderate taxation. Other alternatives are: regulating child-directed advertisements, increasing the participation of the beverage manufacturers and initiation of education programs. However, there is consensus on whether limiting access of SSBs in school could reduce obesity, and other related outcomes.
References
Apovian, C.M. (2004). Sugar-sweetened soft drinks, obesity, and type 2 diabetes. JAMA, 292(8), 978-979.
Babey S., Wolstein J., & Goldstein H. (2013). Still Bubbling Over: California Adolescents Drinking More Soda and Other Sugar-Sweetened Beverages. UCLA Center for Health Policy Research and California Center for Public Health Advocacy.
Bellisle, F., & Drewnowski, A. (2007). Intense sweetener, energy intake and the control of body weight. Eur J Clin Nutr, 61(6), 691-700.
Berger, A. (2004). Ads, Fads, and Consumer Culture: Advertising’s Impact on American Character and Society. Lanham, Md.: Rowman& Littlefield Pub.
Brownell, K., Farley, T., Willett, W., Popkin, B., Chaloupka, F., et al. (2009). The public health and economic benefits of taxing sugar-sweetened beverages. The New England Journal of Medicine, 361(16), 1599-1605.
Chrysochou, P. (2010). Food health branding: The role of marketing mix elements and public discourse in conveying a healthy brand image. Journal Of MarketingCommunications, 16(1/2), 69-85.
HYPERLINK “http://www.ncbi.nlm.nih.gov/pubmed?term=Dubois%20L%5BAuthor%5D&cauthor=true&cauthor_uid=17524711” Dubois, L., HYPERLINK “http://www.ncbi.nlm.nih.gov/pubmed?term=Farmer%20A%5BAuthor%5D&cauthor=true&cauthor_uid=17524711” Farmer, A., HYPERLINK “http://www.ncbi.nlm.nih.gov/pubmed?term=Girard%20M%5BAuthor%5D&cauthor=true&cauthor_uid=17524711” Girard, M., & HYPERLINK “http://www.ncbi.nlm.nih.gov/pubmed?term=Peterson%20K%5BAuthor%5D&cauthor=true&cauthor_uid=17524711” Peterson, K.(2007). Regular sugar-sweetened beverage consumption between meals increases risk of overweight among preschool-aged children. HYPERLINK “http://www.ncbi.nlm.nih.gov/pubmed/17524711” o “Journal of the American Dietetic Association.” J Am Diet Assoc.107(6), 924-3
Gram, M., de la Ville, V., Le Roux, A., Boireau, N., &Rampnoux, O. (2010). Communication on food, health and nutrition: A cross-cultural analysis of the danonino brand and nutri-tainment. Journal of Marketing Communications, 16(1/2), 87-103.
James J, Thomas P, Cavan D, & Kerr D. (2004). Preventing childhood obesity by reducing consumption of carbonated drinks: cluster randomised controlled trial. BMJ, 328, 1237–9.
John, C., & Chad, M.(2012). The medical care costs of obesity: An instrumental variables approach. Journal of Health Economics, 31 (1), 219
Jordan, A., Piotrowski, J., Bleakley, A., & Mallya, G. (2012). Developing media interventions to reduce household sugar-sweetened beverage consumption. The Annals of the American Academy of Political and Social Science, 640(1), 118-135
Kim, D. (2006).Food Taxation and Pricing Strategies to “Thin Out” the Obesity Epidemic. American Journal of Preventive Medicine, 30(5), 430–437
Kleiman, S., Ng, S., &Popkin, B. (2012). Drinking to our health: Can beverage companies cut calories while maintaining profits? Obesity Reviews, 13(3), 258-274.
Lawrence, S., Boyle, M., Craypo, L., & Samuels, S. (2009).The food and beverage vending environment in health care facilities participating in the healthy eating, active communities program. Paediatrics, 123, 292
Maria, A., Lennert, V., Stephen, M., Melanie, Y. & Karen, H. (2013). Eviedence that a tax on sugar sweetened beverages reduces the obesity rate: a meta-analysis. BMC Public Health, 13, 1072
Novak, N. & Brownell, K. (2011). Taxation as prevention and as a treatment for obesity: the case of sugar-sweetened beverages. Curr Pharm Ds, 17(12), 1218-1222
Powell, L., Chriqui, J., & Chaloupka, F. (2009). Associations Between State-level Soda Taxes and Adolescent Body Mass Index. Journal of Adolescent Health, 78, 90-94
Rappange,D., Brouwer, W., Hoogenveen, R. & Baal, P. (2009). Healthcare costs and obesity prevention: drug costs and other sector specific consequences. Pharmaeconomics, 27(12), 1031-1044
Schulze, M.B., Manson, J, E, Ludwig, D.S., Colditz, G.A., Stampfer, M.J., Willett, W.C., & Hu, F.B. (2004). Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women. JAMA, 292, 927-934
Taber, D., Chriqui, J., Powell, L. & Chaloupka, F. (2012).Banning all sugar-sweetened beverages in middle schools: reduction of in-school access and purchasing but overall consumption. Arch Pediatric Adolesc Med, 1666(3), 256-262
Wiecha, J.L., Peterson, K.E., Ludwig, D.S., Kim, J., Sobol, A., & Gortmaker, S.L. (2006). When children eat what they watch: impact of television viewing on dietary intake in youth. Arch Pediatr Adolesc Med, 160(4), 436-442.
Literature Review Coronavirus Pathogenesis
Literature Review: Coronavirus Pathogenesis
Name of Student
Institution
Literature Review: Coronavirus Pathogenesis
Introduction to Coronavirus
-Description of the virus and the group
-Considered emerging pathogens (Martin-Navas & Weiss, 2004).
-SARS infections
Replication of Coronavirus
-The Virion-description of the virion (Weiss & Navas-Martin, 2005).
-RNA Genome
-Virus proteins
Coronavirus types and Diseases
-Murine Coronaviruses
-Human Coronaviruses
-Porcine Coronavirus
-Bovine Coronavirus
-Feline Coronavirus
Avian Coronavirus
The Development and Application of Reverse Genetics Systems
-Full-length CDNA clones
-The MHV genome systems
The Roles of Coronavirus Proteins in Replication and Pathogenesis
-Spike Proteins
-Nucleocapsid proteins
-Membrane proteins
-Internal protein
-Small envelope protein
-Group specific proteins
-Replicase proteins (Weiss & Navas-Martin, 2005)
Mutations of Coronavirus
-Feline Coronaviruses (Licitra et al., 2013).
The outbreak of severe acute respiratory syndrome (SARS)
-Origins
-Pathogens of SARS
-Outbreaks
-SARS Vaccine development
-Treatment of SARS
-Middle East Respiratory System Coronavirus-MERS-CoV (Coleman & Frieman, 2013).
Coronavirus Vaccine Development
References
Coleman, M. C., & Frieman, B. M. (2013). Emergence of the Middle East respiratory syndrome Coronavirus. PLOS Medicine, 9(9) e1003595. Retrieved from http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1003595
Licitra, M.B., Millet, J. K., Reagan, D. M., Hamilton, S. B., Rinaldi, V. D. … Whittake, G. R. (2013). Mutation in spike protein cleavage site and pathogenesis of feline coronavirus. Emerging Infectious Diseases, 19(7).
Martin-Navas, S., & Weiss, R. S. (2004). Coronavirus replication and pathogenesis: Implications for the recent outbreak of severe acute respiratory syndrome (SARS) and the challenge for vaccine development. Journal of Neuro Virology, 10,75-85.
Weiss, R.S., & Navas-Martin, S. (2005). Carnivorous pathogenesis and the emerging severe acute respiratory syndrome coronavirus. Microbiology and Molecular Biology Reviews, 69(4), 635-664.
Literature Review Acute Coronary Syndrome
Literature Review: Acute Coronary Syndrome
Name:
Instructor:
Course:
Date:
Acute coronary syndrome is caused by lack of adequate blood in the heart. In particular, the condition occurs when the coronary arteries are blocked hence limiting their ability to supply oxygenated blood to the heart muscles. Unstable angina refers to the chest discomfort that is caused by the lack of enough blood flow. Unstable angina is more severe compared to stable angina but less severe than myocardial infarction. Unstable angina which is also known as the angina pectoris is characterized by pain in the chest. When the left anterior descending artery is occluded, the walls of the left ventricle, the interventricular septum and other parts are affected. When the right coronary artery is affected the right atrium and the left ventricle become ischemic. On the other hand, when the circumflex artery is occluded the left ventricle, atrium, fasciculus, and the bundle branches become ischemic.
The etiology of this condition focuses on the formation of atherosclerotic plaques. The process starts with endothelial dysfunction. Endothelial dysfunction refers to a condition whereby the inner linings of the endothelium fail to function properly. Remember, the endothelium plays an important role in regulating blood clotting but this function is likely to be affected by several conditions including metabolic syndrome, hypertension, smoking and inactivity. According to Balasubramaniam, Viswanathan, Marshall and Zaman (2012) endothelial dysfunction is characterized by an imbalance between vasodilating and vasoconstricting substances, and an increase in leucocyte adhesion, hence leading to vascular reactivity. Ultimately, endothelial dysfunction leads to atherosclerosis.
According to the American Heart Association, more than a million people are affected by this condition every year. In 2006 alone, more than 1.4 million patients were discharged with a primary or secondary diagnosis of acute coronary syndrome. Currently, there are more than 7 million people living with this condition. Beside death, coronary heart disease can lead to premature, chronic disability to the affected patients. Following a discharge, patients suffering from acute coronary syndrome require re-hospitalization within the first six months. One in every five patients diagnosed with non-ST elevation myocardial infarction and ST-segment elevation, dies after hospitalizations. In total, acute coronary syndrome accounts for half of all mortality related to cardiovascular diseases. The cost of rehabilitating patients with acute coronary syndrome is enormous. The direct costs of treatment are estimated to be $75 billion while the indirect costs of treating patients with acute coronary syndrome are more than $142 billion.
A number of studies have been conducted to examine the threat of Acute Coronary Syndrome among the American population. One such study was conducted by Doyle, Simon, and Stenzel-Poore (2008) using a Behavioral Risk Factor Surveillance. Using self-reported data, the researchers found out that the Southern Eastern states are the ones that are heavily affected by the Acute Coronary Syndrome menace. The study analyzed the risk factors that are responsible for the high prevalence rates in the South Eastern states. One of the risk factor that was examined is the ethnic background and socioeconomic status. The southern eastern part is mainly occupied by minority communities including the blacks and the socioeconomic status of the occupants there is much lower compared to the rest of the nation. The high prevalence rate can also be explained by the lifestyle factors such smoking. The southeasterners also suffer from contributing diseases such as diabetes, coronary heart diseases and hypertension. Due to the high prevalence rates, death rates as a result of Acute Coronary Syndrome are also significantly higher, in the southeastern regions, compared to the other parts around the nation.
Acute Coronary Syndrome has affected other developed countries. In the UK, Acute Coronary Syndrome is a leading cause of disability, and a leading cause of death. Currently, there are around 1 million Acute Coronary Syndrome survivors while an estimated 150,000 people are diagnosed with Acute Coronary Syndrome every year. The majority of those affected by Acute Coronary Syndrome in the UK are the elderly and the leading risk factor is obesity. In England, Northern Ireland, Scotland and Wales, 25% of the whole population is considered obese. The levels of activity among the residents in these four countries are also very low and this explains why Acute Coronary Syndrome is responsible for a significant percentage of deaths that are reported in the country. Overall, £ 8 billion is spent in Acute Coronary Syndrome-related costs.
Developing countries have not also been spared either. In India the prevalence of Acute Coronary Syndrome has been on the rise and this occurrence has been attributed to an increase in the aged population. In Cuba, the crude mortality from Acute Coronary Syndrome is 84 per 100,000 population while in the neighboring countries it is the second leading cause of death (Bonita & Beaglehole, 2871). Just like in India, a significant percentage of the total population in Cuba is made up of elderly people. Incidences of Acute Coronary Syndrome in the developing countries are attributed to several factors. Firstly, low and medium income earning countries account for almost 80% of all chronic noncommunicable diseases that are reported in the world. At the same time, the local population in the developing countries continues to engage in lifestyle choices such as eating high-fat diets, smoking and living a sedentary lifestyle. As the residents continue to adopt the western lifestyle it is expected that the prevalence of Acute Coronary Syndrome will continue to rise. These statistics illustrate to us that Acute Coronary Syndrome is a serious condition which takes huge resources to rehabilitate patients. In addition, the disease has an adverse effect due to the loss in productivity. It is on this basis that it becomes important to evaluate the events surrounding the disease and how it can be prevented and managed.
Literature review
Acute cardiovascular syndrome is a form of cardiovascular disease and is a leading cause of death in the America. Death results when the atherosclerotic plaque breaks up hence stimulating platelet aggregation and thrombus formation. The thrombus formed then prevents myocardial perfusion. Remember, the myocardial cells require oxygen to function properly but the formation of the thrombus restricts the supply of the oxygen hence increasing the myocardial demand for the oxygen. As a result, the ischemic tissues become necrotic leading to decreased renal perfusion. Ultimately, decreased renal perfusion stimulates the release of renin, angiotensin, aldeosterone, antidiuretic hormone hence increasing workload of myocardium.
Balasubramaniam, Viswanathan, Marshall and Zaman (2012) evaluated the role of the endothelial cells in the atherosclerosis process. In the article Balasubramaniam, Viswanathan, Marshall and Zaman Balasubramaniam (2012) argues that endothelial dysfunction plays a pivotal role in the expression of atherosclerosis. When the endothelium becomes impaired it fails to maintain vascular homeostasis. As a result, a number of abnormalities are experienced and they include loss of nitric oxide, over-production of vasoconstrictors, and reduction of the ability to control inflammation, thrombosis and cell growth. The endothelium also plays the role of producing vasodilators such as nitric oxide, and prostacyclin while regulating the effect of vasoconstrictors such as endothelin-1 and angiotensin. The loss of vasodilators and over-production of vasoconstrictors affects the integrity of the arteries. One such vasoconstrictor is angiotensin. Angiotensin not only plays an important role in the loss of normal arterial compliance and patency, but it also mediates the plaque weakening process in a number of ways. Firstly, it leads to the up-regulation of the IL6 gene which is produced by the plaque microphages. Secondly, it leads to the up-regulation of the MMP genes which then lead to the degradation of the plaque fibrous cap. Thirdly, it leads to the activation of the nitrogen-activated protein kinase cascades and tyrosine kinases. Finally, it mediates the stimulation of neo-vascularisation.
In the article, Balasubramaniam, Viswanathan, Marshall and Zaman (2012) further look at the impact of the risk factors such as diabetes in the progression of atherosclerosis. In their view, diabetes mellitus is a strong predictor, and the studies that have been conducted indicate that patients suffering from diabetes have very a little opportunity of recovering from Acute Coronary Syndrome. Mortality rates for diabetes mellitus patients with acute myocardial infarction are also high. In this article, they also look at the role of endothelial NO synthase in the inflammation process. As a vasodilator, eNOS plays an important plays an important role in preventing leukocyte (Balasubramaniam, Viswanathan, Marshall & Zaman, 2012) adhesion while maintaining the antiflammatory state of the endothelium. However, the Acute Coronary Syndrome leads to the low production of eNOS and the endothelial cells are activated to produce vascular cell adhesion molecules such as the VCAM-1 and ICAM-1. These vascular cell-adhesion cells promote the adhesion of the leukocytes to the endothelial surface.
In this article, Balasubramaniam, Viswanathan, Marshall and Zaman (2012) further argue that diabetes increases the platelet aggregation and adhesion process in several ways. Firstly, the condition leads to reduced platelet membrane fluidity. Secondly, the condition leads to increased production of thromboxane, hence increasing platelet sensitivity. Thirdly, it increases the expression of platelet adhesion molecules and the number of platelets. These two actors play an important role in the pro-coagulant activity. Fourthly, diabetes increases the expression of platelet surface receptors and generation thrombin. Fifthly, diabetes mellitus reduces the sensitivity of the platelets to the effects of the vasodilators. Sixthly, platelets of patients with diabetes mellitus are rich in cytokines and chemokines which contribute to inflammation of the endothelium. These findings are supported by Al Thani et. al. (2012) who concluded that diabetes is an independent predictor for presence of polyvascular diseases and Acute Coronary Syndrome.
Another study that was conducted by Zhong, Tang, Zeng, Wang, Yi, Meng, Mao, and Mao (2012) investigated the role of cholesterol content in atherosclerotic plaque progression. Zhong et al. (2012) used a sample of 136 participants. The researchers assessed the cholesterol content of erythrocyte membranes. It is well acknowledged that cholesterol plays an important role in plaque formation. The key feature of the plaque formation is the erythrocyte membrane. Erythrocyte membrane is a key source of cholesterol in plaques. Their findings are supported by Giannoglou,Koskinas, Tziakas, Ziakas, Antoniadis, Tentes, and Parcharidis (2009) who found out that CEM in Acute Coronary Syndrome patients is significantly higher that in patients with stable angina pectoris. In the study, Zhong, Tang, Zeng, Wang, Yi, Meng, Mao, and Mao (2012 also (2012) investigated some of the factors that determine the size of the plaque in the artery. Obviously, the amount of the cholesterol determines the size of the lipid core. The researchers concluded that erythrocytes played a major role in plaque expansion by increasing the lipid content. In addition, they argued that cholesterol encouraged apoptosis of macrophages and formation of foam cells.
The role of the low-density lipoproteins as a cause of Acute Coronary Syndrome was investigated by Meisinger, Baumert, Khuseyinova, Loewel, and Koenig (2005). Very Low-density lipoproteins are secreted from the liver, and are then converted to low-density lipoproteins (LDLs). LDLs may accumulate in the artery wall if their rate of removal is low (Meisinger, Baumert, Khuseyinova, Loewel, & Koenig, 2005). The LDLs stimulate the endothelial cells to express the monocyte chemotactic protein-1 (Meisinger, Baumert, Khuseyinova, Loewel, & Koenig, 2005). MCP-1 then attracts monocytes from the blood. In addition, LDLs encourages differentiation of monocytes into macrophages. Macrophages promote the formation lipid-cell foam cells, which are the hallmark of the atherosclerosis process. Following this narration it is rather apparent that low-density proteins mark the start of atherosclerosis process, and its subsequent progression.
Plaque rupture
According to Kumar and Cannon (2009) the molecules in the endothelium mediate the adhesion of leukocytes on the endothelial surface. The monocytes penetrate the endothelial wall, where they interact with oxidized LDL, transforming into foam cells. The foam cells produce cytokines and other substances that maintain atherosclerosis progression. The plaque usually has a thin fibrous cap which is destabilized by the inflammation cells such as the monocytes, macrophages and T-cells. In the article titled, Coronary events, Armin, Masataka, Renu and Valentin (2012) revisit how the plaque forms and how it later erupts. An atherosclerotic plaque normally has a large necrotic core but a small layer of the fibrous cap. The expansion of the atherosclerotic plaque is facilitated by the accumulation of free cholesterol, and macrophage infiltration. The fibrous cap only has a few smooth muscle tissues and is often inhabited by macrophages and T lymphocytes. Once the fibrous cap erupts, it exposes the thrombogenic materials to the blood stream. Following the rupture of the plaque, thrombi are formed. It is the rupture of the fibrous cap that leads to the development of unstable angina and myocardial infarction.
A lot of research has focused on how the plaque ruptures. One likely cause is the accumulation of T-lamphocytes and microphages-derived foam cells which secrete cytokines and proteolytic enzymes leading to the depletion of smooth muscle cells. The apoptosis of smooth muscle cells is promoted by the mast cells which are abundant in the plaque. The reduction of the smooth muscle cells impairs the repair process. Remember, smooth muscle cells produce the cap-stabilizing collagen and so a significant reduction of the cells is likely to have deleterious effects. Plaque rupture is also facilitated by the blood flow-induced shear stress. It is assumed that as the plaque grows, the tensile stress on the plaque shoulders increases hence leading to fissuring and subsequent rupturing. Armin, Masataka, Renu and Valentin (2012) found out that areas of low shear stress had advanced plaques than areas with high stress. Armin, Masataka, Renu and Valentin (2012) further notes that not all plaque ruptures lead to coronary events.
Armin, Masataka, Renu and Valentin (2012) examined the atherosclerotic process and the effect it has on the size of the artery. During the initial stage, the size of the artery is usually normal. In the second stage, as the plaque formation progresses, the artery remodels itself to avoid lumen encroachment. In the third stage, the plaque ruptures and hemorrhages leading to formation of intramural thrombi. Armin, Masataka, Renu and Valentin (2012 notes that mostly the plaque heals and continues to grow. Alternatively, the thrombogenic materials may be embolized distally leading to coronary arterial insufficiency or asymptomatic micro-infarctions. In the fourth stage, if the right conditions exist, the rupture of the plaque leads to the occlusion of the affected arteries.
In the article, Armin and his colleagues also looked at the interplay of factors that contribute to acute coronary event risk (2012). One factor is plaque burden which is determined by the blood viscosity, platelet function, stress and smoking (Armin, Masataka, Renu & Valentin, 2012). The other coronary plaque characteristic is lumen encroachment which depends on shear stress, circadian variation, obesity, catecholamine surge and pollution (Armin, Masataka, Renu & Valentin, 2012). Other coronary plaque characteristics include lesion locations, plaque composition, plaque biology, plaque configuration, endothelial dysfunction and plaque remodeling (Armin, Masataka, Renu & Valentin, 2012).
On their part, David and Valentin (1999) looked at the activities surrounding the atheromatous plaques. The formation of plaques according to David and Valentin (1999) can be traced to the early lesions. Early lesions then grow bigger as the extracellular lipid and cholesterol content increase and fibrous cap grow thin. This development according to David and Valentin (1999) occurs in 5 phases. During phase 1 the development of lesion types I-III occurs while in the phase 2, lesion types IV and Va develops (David & Valentin, 1999). Plaque disruption starts from phase 3, eventually leading to the growth of more complicated plaques. The acute coronary syndrome occurs in phase IV, when plaques are more complicated (David &Valentin, 1999). However, plaques may fail to rupture and occlude the affected arteries. Such plaques characterize the last stage of the plaque development.
Clinical sequellae and symptoms
The eruption of the fibrous cap exposes the content of the plaque to the blood elements. In addition, an alteration of the blood flow is experienced around the ruptured plaque and the blood flow supporting myocardial distal is reduced (David &Valentin, 1999). Vasoconstriction at the site of the ruptured plaque makes coronary events to become much more severe. (David &Valentin, 1999) If the ruptured plaque does not significantly disrupt the flow of the blood, only an asymptomatic progression of the lesion is experienced (David &Valentin, 1999). On the other hand, if the rupture leads to complete vessel occlusion, acute myocardial infarction results (David &Valentin, 1999). The common symptoms of Acute Coronary Syndrome include chest pain, arrhythmia, shortness of breath, fatigue, weakness, heart palpitations, nausea, numbness, confusion, slurred speech, vertigo and headache.
Diagnosis
Detection of atherosclerosis is one of the main objectives of the diagnostic tools. One such advancement is the use of plasma markers. One of the markers that have been used widely is the C-reactive protein and the lipoprotein associated phospholipase A2. Such markers are used to predict coronary events. Using peripheral blood has become popular due to the low cost that is associated with this process. An alternative method that is used in diagnosing coronary patients is the non-invasive imaging. Some of the imaging tools that can be used for identifying vulnerable carotid plaques include: ultrasound, MRI, nuclear imaging and X-Ray multi-detector. A CT angiogram and a nuclear scan could also be used to check the site of rupture and identify whether the arteries are constricted or blocked. Other diagnostic tests include an electrocardiogram, blood tests, chest X-ray, and coronary angiogram.
Interventions
Reperfusion therapy
In the article titled, Acute coronary syndromes: diagnosis and management, Cannon and Kumar (2009) looks at the interventions for the acute coronary syndrome. Reperfusion therapy has been found to improve patient outcomes. The efficacy of reperfusion therapy in acute coronary syndrome was tested in a study that was conducted by Desai (2008). The 80 participants in this study were all Acute Coronary Syndrome patients. The two researchers also compared the efficacy of the percutaneous balloon angioplasty and systematic thrombolysis. The two interventions were found to increase systolic and left ventricle functions.
Antithrombotic therapy
According to Kumar and Cannon (2009) the aim of this intervention is to maintain the patency of the infarct-related artery. Antithrombotic therapies are augmented by anti-platelet strategies such as aspirin and glycoprotein IIb/IIIa antagonists. Antianginal therapy could also be used and use of nitrates to reverse the vasospasm, reduce the coronary blood flow at the site of rupture and the myocardial oxygen demand.
Coronary surgery and angioplasty
It is apparent that administration of anti-platelet and anti-thrombotic drugs improves the chances of survival to the patients. These drugs are often used before percutaneous coronary or surgery revascularization is performed. The coronary surgery is performed to bypass the affected portion of the coronary artery. The grafted artery goes around the area with the plaque, a process that creates a new path for oxygen-rich blood. The efficacy of coronary artery bypass surgery is supported by a study that was conducted Kumar and Cannon (2009). All the participants in this study had ST-segment elevation myocardial infarction. The result of the study indicates that high-risk patients who undergo surgery intervention have very high chances of survival. An alternative to the bypass surgery is the percutaneous coronary surgery otherwise known as coronary angioplasty or balloon angioplasty. The process entails using a catheter with a balloon at the tip. Once in place, the balloon inflated to compress the plaque against the artery wall. This process targets unstable plaques which have thin fibrous caps, lipid full macrophages, and deficient smooth muscle cells. During balloon angioplasty, a stent is used to maintain the patency of the occluded arteries.
References
Al Thani, H., El-Menyar, A., Alhabib, K., Al-Motarreb, A., Hersi, A., Alfaleh, H., Asaad, N., Saif, S.A., Almahmeed, W., Sulaiman, K., Amin, H., Alsheikh-A., Alnemer, K. & Suwaidi, J. (2012). Polyvascular disease in patients presenting with acute coronary syndrome: its predictors and outcomes. Scientific World Journal, 2012, 284851
Armin, A., Masataka, N., Renu, V., & Valentin, F. (2012). Acute coronary events. Circulation, 10(1), 1147-1156
Balasubramaniam K, Viswanathan G, Marshall S, & Zaman A. (2012). Increased Atherothrombotic Burden in Patients with Diabetes Mellitus and Acute Coronary Syndrome: A Review of Antiplatelet Therapy. Cardiology Research and Practice, 2012, 1-18
Bonita, R., & Beaglehole, R. (2007). ACUTE CORONARY SYNDROME prevention in poor countries: Time for action. Stroke, 38(11), 2871–2
David, E. G. & Valentin, F. (1999). Pathophysiology and clinical significance of atherosclerotic plaque rupture Cardiovascular Research, 41(2), 323-333
Desai, N.D. (2008). Pitfalls assessing the role of drug-eluting stents in multivessel coronary disease. Annals of Thoracic Surgery, 85 (1), 25–7.
Doyle, K. P., Simon, R. P., & Stenzel-Poore, M. P. (2008). Mechanisms of ischemic brain damage. Neuropharmacology, 55, 310.
Giannoglou, G., Koskinas, K., Tziakas, D., Ziakas, G., Antoniadis, A., Tentes, I., & Parcharidis, G. (2009). Total Cholesterol Content of Erythrocyte Membranes and Coronary Atherosclerosis: An Intravascular Ultrasound Pilot Study. Angiology, 60(6), 676
Kumar, M.D. & Cannon, C. (2009). Acute coronary syndromes: Diagnosis and Management. Mayo Clinic Proceedings, 84(10), 917-938
Meisinger, C., Baumert, J., Khuseyinova, N., Loewel, H. & Koenig, H. (2005). Plasma oxidized low-density lipoprotein, a strong predictor for acute coronary heart disease events in apparently healthy, middle-aged men from the general population. Circulation, 2; 112(5):651-7.
Zhong, Y., Tang, H., Zeng, Q., Wang, X., Yi, G., Meng, K., Mao, Y., & Mao, X. (2012). Total cholesterol content of erythrocyte membrane is associated with the severity of coronary artery disease and the therapeutic effect of rosuvastatin. Upsala Journal of Medical Sciences, 117(4): 390–398
