Recent orders
natural killer cells
Victoria Brown
Biol 454L Thursdays 11:30-2:30pm
In 1975 NK cells also known as “natural killer cells” were discovered by a man named Rolf Keossling and his team in Sweden. There are two different types of lymphocytes known as the B cells and T cells but, so are NK cells. Lymphocytes are white blood cells that is one of the body main immune cells. NK cells are the most aggressive and lymphocytes that have no immunological memory. They estimate about 5-10% of the circulating lymphocytes population. When It comes to tumors, cancer and unrecognized virial infected cells NK cells play a major role in rejecting and killing them in the system. Although NK cells ae in the same family and progenitor as B and T cells; NK cells have a different ability to attack and kill tumor cells.
Natural killer cells have the ability to attach and kill tumor cells without activating to an antigen and presenting cells, and that’s how the name “natural killer” is another name for NK cells. Nk cells are a innate effector lymphocytes that are divided into cytokines that produce CD56 “bright” and CD56 “dim”. They also protect against many various infection’s microbes’ diseases. NK cells are found in multiple areas such as in the bone marrow, uterus, spleen, lungs, lymphoid tissues, thymus etc. When NK cells are working, they look for early cancer cells, diseases and cells that are not noticed in the body before. NK cells are activated by either macrophage cytokines or interferons and can respond indirectly or directly. If its directly they respond by recognized bad virus cells and indirectly means they are working with the dendritic cells that express toll like receptors that responds to microbes from secrete cytokines.
When a virus enters the system, it will multiply and copy on to health cells. NK cells work by getting in contact with the target and aims its lethal Tucson’s that will produce a hole in the cell they are targeting in the cell membrane and will destroy the cancer cell membrane and cell. It will be deleted to its death and this process is called that is called apoptosis manners. Apoptosis manners simply kills in a selective manner that is designed to kill cells. After the NK cells have attached and killed the cell, they are able to unattached and attach on to different abnormal cells in the system. When NK cells have moved on to look for more abnormal cells the old cells that have been attacked and deleted sometimes takes up to 24 hours to establish and separate themselves from different organs and disappear for good.
Stepping into a public place where thousands of people of have been you can be exposing yourself to bad bacteria and viruses you can’t see. NK cells are used in are everyday life because, each time you go into a area where multiple people have been you are at risk of touching or breathing another person germs. When a cold enters a body, it is the NK cells job to go and kill before hurting and affecting other healthy blood cells in the body. Many normal healthy cells will express MHC 1 receptors; which are antigen that alerts the immune system to viral infected cells. They can be expressed on the surface of the cell are present by peptide fragments from proteins. When NK cells recognize an MHC 1 it will prevent it from killing the cell.
In 2019 there was a virus discovered called Coronavirus 2019 that turned into a dangerous a global pandemic. Coronavirus disease 2019 abbreviated as COVID-19 is a new virus-related contagion triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; originally abbreviated as 2019-nCoV, a new beta coronavirus initially recognized during an outbreak of respiratory infection cases in Wuhan City, Hubei Province, China. After a few weeks, the illness became a pandemic with 353,334 confirmed demises and 5,593,631 cases reported as of May 28. The review of latest statistics highlights the disregulated immune reaction and its inflammatory element as the leading cause of mortality and morbidity, underscoring the necessity of an improved understanding of the early occurrence that form the infection host retort in COVID-19. In this case, it is valuable remembering that the constituents of the inborn immune structure act as main responder for the discovery and clearance of virus-related contagions. Inborn immune cells discharge proinflammatory cytokines which constrain virus-related reproduction, provoke the adaptive resistant reaction, and recruit additional resistant cells to the place of infection. The employment of an effectual immune reaction is a vital feature in the clearance and control of virally infested cells. Certainly, adaptive and innate immune reactions work together to guard the host against microbial infections. Assumed the diverse regulatory and antiviral functions of natural killer (NK) cells, they may perhaps be powerful and potent immune associates in the worldwide fight against COVID-19.
Reference
Demaria, O., Carvelli, J., Batista, L., Thibult, M. L., Morel, A., André, P., … & Vivier, E. (2020). Identification of druggable inhibitory immune checkpoints on Natural Killer cells in COVID-19. Cellular & molecular immunology, 17(9), 995-997
Dong, E., Du, H., & Gardner, L. (2020) An interactive web-based dashboard to track COVID-19 in real time The Lancet infectious diseases, 20(5), 533-534
Hollander, J. E., & Carr, B. G. (2020). Virtually perfect Telemedicine for COVID-19 New England Journal of Medicine, 382(18), 1679-1681.
Maucourant, C., Filipovic, I., Ponzetta, A., Aleman, S., Cornillet, M., Hertwig, L., … & Cuapio, A. (2020). Natural killer cell immunotypes related to COVID-19 disease severity. Science Immunology, 5(50).Mehta, P., McAuley, D. F., Brown, M., Sanchez, E., Tattersall, R. S., Manson, J. J., & HLH Across Speciality Collaboration. (2020). COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet (London, England), 395(10229), 1033
Victims and Victim Programs
Victims and Victim Programs
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Every single day thousands of people fall victim to a crime. A child walking home from school could be abducted, a woman walking home in the dark could be raped, a teenager could be mugged in a dark alley, and a violent spouse could break their partner’s nose. All of these crimes result in the victimization of one party. These crimes affect victims in various ways, often destroying their mental, emotional, social, and physical health. The government and different non-governmental bodies have made resources available to victims of crimes to help them get justice and heal from their ordeals. Some key areas in addressing the topic of victims are crimes that lead to victimization, the costs and effects of victimization, and the programs available to victims.
Crimes that lead to Victimization
Victims bear the brunt of crimes, although they do not receive the attention that they deserve for the terrible experiences they endure. Some of the major crimes resulting in victimization include assault, rape, child abuse, drunk driving, arson, and drug abuse. The number of child abuse cases is difficult to estimate as many cases go unreported or uninvestigated. Parents and guardians are expected to be the primary caregivers who keep their children safe, but sometimes this is not the case. The Department of Child and Family Services is tasked with responding to any issues related to child abuse. In the United States, the National Incidence and Prevalence Survey of Child Abuse and Neglect tracks child abuse incidences in the country (Lee, 2019). One of the significant challenges with child abuse statistics is that they are mainly obtained from adults, meaning they may not convey an accurate picture.
Rape is another serious crime with thousands of victims. It is, however, difficult to get an accurate number of victims for this crime because many cases go unreported. Contributors of unreported rapes are victim-shaming (Felson & Palmore, 2018), lack of evidence, fear on the part of the victim, and the relationship between the rapist and the victim. One example of victim-shaming is that victims are often told they must have done something to deserve their abuse, or they did not try hard enough to stop it. Male victims of rape are often shy to report because they might be ridiculed. The National Sexual Violence Center reports that in 2018, the incidents of rape stood at 734,630. Only 25% of these cases were reported to the police (Morgan & Oudekerk, 2019), showing that most victims did not get any justice. Rape is one of the crimes where victims suffer in silence due to various factors, something that causes a lot of trauma and suffering.
Assault as a crime has the highest number of victims every year. Assault takes many forms, one example being domestic violence. Assault may or may not result in injury. There are so many types of assault, ranging from verbal abuse and threats to bodily harm that results in injury. Examples of assault include throwing objects, threats of violence and death, verbal insults, pointing a weapon at someone, among many others. Intimate partner violence is a serious issue because many cases of domestic assault go unreported, mainly due to fear on the part of the victims. Unfortunately, some of these assault cases result in death. The Bureau Of Justice Statistics reports an average of 6 million instances of violent assault in the year 2018 (Morgan & Oudekerk, 2019). An important point to note is that assault can either be simple or aggravated depending on the characteristic of the crime. Simple assault does not involve a weapon and may result in either no injury or minor injuries. Aggravated assault involves a weapon, which may be used to attack a person or used as a threat of attack. Other crimes that lead to victimization include drunk driving and arson.
Effects and Costs of Victimization
Being the victim of a crime has many devastating consequences on one’s mental, emotional, physical, and social wellbeing. These consequences are both tangible and intangible. One significant tangible effect of being a victim of a crime is the medical costs associated with the crime (Lugo et al., 2018). The extent of injury depends on the nature of the crime. For example, if the victim sustains severe knife or gunshot wounds, they may need extensive surgery, which is quite costly. Less serious injuries also have medical costs associated with them, as even minor ones require a trip to the emergency room. Other medical expenses include the cost of transportation to a hospital in case of an emergency, costs of rehabilitation, and funeral costs in case of death. In many cases, victims and their families have to foot these bills, causing imposing financial consequences and strain upon them.
Being the victim of a crime severely affects the mental health of a victim and those around them. Victims often suffer from mental health struggles in the aftermath of their crimes, which might go on for the rest of their lives. An example of this is paranoia and fear of public spaces. Victims may live the rest of their lives constantly looking over their shoulders, thinking that someone is following them. Victims could also suffer from other problems such as hallucination, depression, anxiety, and dissociative personality disorder (Scott et al., 2018). Victims of serious crimes such as aggravated assault, rape, and domestic violence often suffer severe mental health disorders due to their ordeal. Treatment of these mental illnesses also puts a financial strain on the victims and their families. Victims may need long-term therapy for their mental health struggles to help them lead a relatively normal life.
Victims could lose some valuable property as a result of crimes committed against them. This is usually most pronounced during crimes such as burglary and arson. Property taken and not recovered factors into the tangible costs of being a crime victim. Damaged property is also a serious issue, especially where the property was uninsured. The cost of processing an insurance claim in terms of money and time also puts strain on the victim of the crime.
Victims’ productivity in various areas of their lives suffers as a result of a crime committed against them. They may be forced to skip school, work, or other important events for a period after. Skipping work could lead to a person being fired or going on unpaid leave, which causes a loss of wages for that person and their dependents. Productivity costs are not just on the victims but also on their family, coworkers, employers, schoolmates, and other people close to them. For example, a family member may need to stay home from work or school to care for a victim of a crime, affecting their productivity. Some victims of crimes end up permanently disabled, requiring long-term care, or they may even lose their lives.
For children, the consequences of crimes bear a lot of weight. The children may not fully understand what happened to them at a young age. Crimes tend to affect children’s development; for example, abused children have delayed milestones such as talking and socializing with others. Jud et al. analyzed the effects in a published article titled, ‘On the incidence and prevalence of child maltreatment: a research agenda.’ The authors explain that the impacts of child abuse are wide-ranging and have lasting effects well into adulthood and even old age. One of the consequences is on the children’s psychological wellbeing. Abused children tend to suffer from mental problems such as depression, paranoia, low self-esteem, and even suicide (Jud et al. 2016). Their social lives are also affected, and the abused children tend to keep to themselves or isolate due to the trauma they endured. All of these patterns, if left untreated, persist till later in life, negatively affecting their quality of life.
There are other costs related to victims of crimes, such as the costs of first responders like police and fire departments (Lugo et al., 2018). When a crime happens, the most practical course of action is to alert the police. This may be done by concerned citizens, witnesses, and victims of the crime. Police and other response teams are valuable resources who have to be paid for their role in keeping us safe. Additionally, there have to be investigators and other professionals who look into the crime to determine the extent of damage and find the criminals. All of these resources utilized in aid of the victim cost money and contribute to the overall costs of being a crime victim. Crimes do not just affect individuals but communities as a whole.
Victim Programs
Over the years, response programs for victims have improved tremendously with more resources allocated to these programs. Today, victims of crime can get the help they need with a mere phone call. The federal Office for Victims of Crime website details the growth of the victim program over the years. California made history as the first state to set up a victim compensation program in the year 1965, and other states soon followed suit. In 1972, Missouri, California, and D.C. set up the country’s first victim assistance programs (Miers, 2014). Congress passed the Child Abuse Prevention and Treatment Act in 1974, allocating resources for abused and neglected children. Four years later, two critical federal programs were set up to support victims; the National Coalition against Sexual Assault (NCASA) for victims of sexual violence and the National Coalition against Domestic Violence (NCADV) for battered women. All of these organizations lay the foundation for improved support and services for victims of various crimes.
President Ronald Reagan stepped up the support for crime victims by setting up the President’s Task Force on Victims of Crime which would explore the experiences of crime victims in the justice system. The task force reported that victims play a critical role in the criminal justice system, so it was important for people to understand their experience. Victims had their lives forever changed as a result, and taskforce members got to understand this as they met with many victims. The task force made many recommendations, one of which was the establishment of the Office for Victims of Crime (OVC) in 1988 to administer the Crime Victims Fund across the country. Over the years, the fund has deposited hundreds of millions of dollars which have been critical in aiding victims of crimes. The OVC plays vital roles, including creating legislation to protect the rights of victims, training professionals dealing with victims (Office for Victims of Crime, 2019), and establishing a national resource center.
The passing of the Violence Against Women Act (NAWA) in 1994 by Congress marked an important milestone in protecting female victims of crime, specifically sexual assault and intimate partner violence. One landmark case in 1988, State v. Ciskei became the first to allow an expert to testify on the mental state of rape victims. The expert explained that when one has been a victim of repeated physical and sexual abuse, they may not immediately alert the authorities on their abuse. This is referred to as battered woman syndrome (Khanna & Sachdeva, 2015), which marked an important step against victim shaming and blaming by understanding how abuse history affects the victim’s response. There are many other programs designed for victims from specific groups that continue to promote victims’ rights to this day. One of these is the National Center on Elder Abuse, which collects and provides data and resources on elder abuse around the country.
The legislature has passed many other bills designed to promote victims’ rights over the years, giving the victims hope that justice shall be served. Drunk drivers cause a lot of injuries and deaths to innocent victims every day. The Federal Drunk Driving Prevention Act passed in 1988 set the legal drinking age at 21, reducing the chances of younger individuals drinking and driving due to a proper lack of judgment. Additionally, Congress passed legislation proposed by Mothers against Drunk Driving that blocked drunk drivers from filing for bankruptcy and avoiding charges. Children are an essential part of victim protection and rights, and there are various laws that protect and uphold the rights of child victims. One of these is the PROTECT Act of 2003, more popularly referred to as the Amber Alert (Griffin et al. 2016), where information on missing or kidnapped children is broadcast to the community to facilitate faster response.
These victim programs offer a wide range of protection and services for victims of crimes. Before these programs were established, victims were primarily left on their own, exposed to many challenges. For example, rape victims could be ignored by authorities if they could not afford their own legal resources. Such situations left victims feeling alone, angry, ashamed, and blaming themselves for what happened to them. Today, various resources are available to ensure that victims of crimes receive the help and the justice that they need to move forward with their lives. Some of the resources offered under victim programs include shelter, advocacy, medical services, legal services, mental health services, and monetary compensation for damage, injury, and loss. The criminal justice system recognizes the crucial role that victims play and that they need a lot of support and protection.
In summary, victims are a significant part of the criminal justice system. In many cases, people find reasons to blame the victims, shame them for their ordeal and leave them without the justice they deserve. Being the victim of a crime takes a significant toll on one’s life. The most common crimes that lead to victimization include rape, assault, and child abuse, among others. Depending on the nature of the crime, victims could be afraid to come forward due to fear of repercussions. Crimes affect victims’ emotional, social, mental, and physical wellbeing. Over the years, the government has created various programs to help victims of different crimes. These programs are usually tailored specifically to the victims of a particular crime so that trained professionals work with victims. Children, the elderly, victims of rape, victims of domestic violence all have different organizations mandated to help them navigate the aftermath of their crimes. For victims, getting justice is one of the most critical paths to healing. A rape victim will breathe easier knowing their rapist has been punished and that they will no longer hurt anyone else. Society needs to take a more empathetic stance towards victims, and the criminal justice system needs to ensure that justice is served for every crime committed.
References
Griffin, T., Williams, J. H., Wooldredge, J., & Miller, D. (2016). Does AMBER Alert ‘save lives’? An empirical analysis and critical implications. Journal of crime and justice, 39(4), 490-511.
Jud, A., Fegert, J. M., & Finkelhor, D. (2016). On the incidence and prevalence of child maltreatment: a research agenda. Child and adolescent psychiatry and mental health, 10(1), 1-5.
Khanna, D., & Sachdeva, A. (2015). Battered woman syndrome: its repercussions and implications on women of the present era. International journal of clinical and experimental medical sciences, 1(2), 7-10.
Lee, S. (2019). “Crime Victim Awareness and Assistance Through the Decades.” National Institute of Justice (NIJ), US Department of Justice, Office of Justice Programs, & United States of America.
Lugo, K., Przybylski, R., Farley, E., Howley, S., Liberman, A., Yahner, J., … & Garcia, O. (2018). Estimating the financial costs of crime victimization. Office of Justice Programs. https://www.ojp.gov/pdffiles1/nij/grants/254010.pdfMiers, D. (2014). Offender and state compensation for victims of crime: Two decades of development and change. International Review of Victimology, 20(1), 145-168.
Morgan, R., & Oudekerk, B. (2019). Criminal victimization, 2018 (NCJ 253043). U.S. Department of Justice, Bureau of Justice Statistics. https://www.bjs.gov/content/pub/pdf/cv18.pdfOffice for Victims of Crime (OVC), US Dept of Justice, Office of Justice Programs, & United States of America. (2019). OVC Help Series for Victims of Crime.
Felson, R. B., & Palmore, C. (2018). Biases in blaming victims of rape and other crime. Psychology of Violence, 8(3), 390.
Scott, K. M., Koenen, K. C., King, A., Petukhova, M. V., Alonso, J., Bromet, E. J., … & Kessler, R. C. (2018). Post-traumatic stress disorder associated with sexual assault among women in the WHO World Mental Health Surveys. Psychological medicine, 48(1), 155.
victimology
Victimology
CJUS280
Student’s Name:
Institution:
Victimology
There has been several victim advocacy programs that have been developed in United States among other countries to serve different types of clients. Victim advocacy programs are programs that help to support victims of crime through offering emotional support, helps in finding resources and other helpful information and services. This services ranges from; sexual assault advocate programs, victim compensations, domestic violence programs, offering victim advocates, public education programs, crisis intervention, among others. This essay will however discuss two victim advocacy programs (Rape Victims Advocacy program (RVAP) and The Family Advocacy Victim Advocate Program (FAVAP) while comparing and contrasting them.
Compare and contrast the two different programs
Rape Victims Advocacy program is a victim advocate for sexual assault and prevention education program for individuals of any gender, culture, identity, age etc. RVAP offers confidential and free trauma-informed advocacy to those going through sexual violence as well as promoting social changes in their lives through prevention education. It serves individuals who have been impacted with sexual violence in Lowa countries: Lee, Johnson, Lowa, Cedar etc (The University of Lowa, 2017). While Rape Victims Advocacy program deals with sexual assaults issues only, Family Advocacy Victim Advocate Program on the other hand provides wide-ranging liaison and assistance for and to victims of spouse abuse in addition to sexual assaults. Family Advocacy Victim Advocate Program also provides safety planning, crisis intervention, help in obtaining medical treatment for different injuries, offers information on some legal rights as well as legal proceedings and providing referral to civilians and military shelters, food and clothing to victims (Army Community Service, 2016). It is therefore evident that the two has similarities in their target on sexual assaults victims. However, Family Advocacy Victim Advocate Program goes to an extent of covering domestic abuse victims. Both programs deals with prevention education program for individuals of any gender, culture, identity, age etc.
How effective do you feel are your selected victim’s advocacy programs? Why?
Following a preliminary review of the two advocacy programs’ websites, I believe both advocacy programs are effective as their activities define their success. Family Advocacy Victim Advocate Program is effective as it serves as the main POC which is integrated with FAP in ensuring that complete and timely care has been provided to domestic abuse victims and sexual assaults. Victim advocates provides the victim with information on some of the resources available in assisting such victims. Additionally, victim advocates ensure that they maintain contact of the victim throughout the victim’s medical journey, investigative as well as through counselling and processes of judicial. Also, FAVAP has a 24-hour hot line service in order for the victims to get in touch with them any time. RVAP on the other hand has collaborated with different other community initiatives in running its programs. For instance, it has collaborated with lowa State University in order to ensure that it helps university youths as well. The collaboration of RVAP with the university shows its interest in reaching a bigger number of people (students) who are prone to rape cases.
What types of victims do you think benefit most from the selected victim’s advocacy programs? Explain your reasoning.
As noted from the above statements on the mission of both programs, it is evident that both advocacy programs benefits victims of sexual assault. RVAP benefits sexual assaults victims of both gender. The same applies to FAVAP which benefits victims of sexual assault as well as domestic abuse individuals. Vast majority of victims benefiting FAVAP are went through emotional abuse, economical abuse, verbal abuse, physical abuse among others (Mercurio-Sakwa, 2016). Both gender (male and female) benefit in both programs. However, female benefits mostly in RVAP as they are more prone to rape than men. Additionally, research shows that 85% of women are victims of domestic violence hence explaining that most women than men benefit this two programs.
If you were able to modify a single element or aspect of each program, what would it be? Explain why.
Family Advocacy Victim Advocate Program, does not have enough trained counsellors since not many people volunteer to work for non-government organization. In this case, I would adopt a part time agreement with some local professionals in order to donate some of their free time during weekends and in the evening to help in the program. This will help the Family Advocacy Victim Advocate Program without adding unnecessary costs or depleting their funds. IN RVAP, I would consider modifying their engagement with different other institutions as well as organization and reaching the community directly. While collaboration is very important, it is important too to reach the community directly through conducting survey in different households or institutions.
Do you think the media plays a role in addressing the needs of crime victims? Explain. If yes, does it have a mostly positive or mostly negative impact? Why?
Yes, I believe the media plays an important role in addressing the needs of crime victims. The news media plays an important role through providing the public with important information concerning the extent and nature of crimes happening in the community and the efforts been taken to prevent such crimes and help victims. Sensitive and timely coverage of victim cases through the media has always been helpful and most specifically in emergency of cases that the public need to be aware of (Canadian Resource Centre for Victims of Crime, 2017). The media raises positive degree of public concern on what measures need to be taken in order to ensure safety of different crimes.
Reference
Army Community Service. (2016). Family Adocacy Victim Advocate Program. Retrieved from
http://www.hoodmwr.com/acs/apb_favap.html
Canadian Resource Centre for Victims of Crime (2017). Victims and the media. Retrieved from
https://crcvc.ca/publications/media-guide/victims-and-media/
(2016). “Judicial Shortcomings for Domestic Violence Victims.” SHARE, INC. Retrieved from
https://sharemorgancounty.org/2016/05/13/judicial-shortcomings-for-domestic-violence-victims/
The University of Lowa. (2017). Rape Victims Advocacy program. Retrieved from
https://rvap.uiowa.edu/about/
