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Valediction
Valediction
Outline
Sherman Alexie’s Valediction is a poem featured in the book Best American Poetry as edited by David Lehman and Kevin Young in 2011. The following work involves the analysis of the poem and a discussion on the various poetic tools employed annexed alongside an opinion on the suitability of the work for inclusion in the syllabus. In view of the entire article’s structure, an introduction ushering in the content appears in the beginning, followed up by a brief highlight of Sherman Alexie’s works and career. The main discussion contemplates on the poem Valediction, giving a detailed opinion on various poetic perspectives before the conclusion. Literature consultation regarding the author and the poem facilitates the development of the opinion and backs up the thesis statement established at the end of the introduction.
The title Valediction generates the idea of some troubled setting for the poem, which facilitates a quick generation of the theme of the poem. From the basic definition of the term valediction, it is possible to depict the central message of the poem with some form of trouble expected. Bidding farewell entails a certain level of painful departure and detachment of persons and upon reading the title, it emerges that the author generates such a sorrowful theme in the poem. The poet presents the central theme using a brief and a simplified format with the choice of words particularly standing out clearly in the eight double-lined verses. The approach adopted by the poet in the design of the poem augurs well with the theme of a tragic ending of the life of the main character, making precision and accuracy important. Without the combination of precision and simplicity, the appearance of the poem as a strong presentation of the central theme of struggle would be difficult.
Sherman Alexie is among the most seasoned of American contemporary artists with a wide spectrum of artistic genres including film, novel, short story, screenwriting, and poetry. Having a wide range of artistic occupations, Sherman was able to rise as an award winning literary icon through early 1900s to date, amassing several awards in the process. Born in 1966 with hydrocephalus, a condition where there is excessive secretion of brain fluid in the cranial cavity, Alexie underwent a life threatening surgery, which he survived. A difficult childhood coping with the condition coupled to bullying and teasing by other children did not intimidate him to rise to academic excellence witnessed as early as by the age of twelve. He had an exemplary life at school and his gradual recovery gave him the courage to take up several roles as a student leader in various disciplines including debate and sports.
Alexie’s professional orientation manifests itself with a special bias on hopelessness and poverty among the marginalized communities in the United States, particularly among the Native American population (Johansen 7). Perhaps the central theme in the poem Valediction falls within the best range of issues that his traditional orientation captures. With regard to the sadness in a majority of the collection of his works, certain factors of presentation must come out clearly including precision, simplicity, and accuracy. In line with a passionate motivation from personal life experiences, Alexie captures the theme of suffering and helplessness in a unique way than many authors would. The perspective of suffering, taken by someone who is in terms with life encounter with sadness, enables the author to present an interesting point of view on the subject matter than many other writers. In the poem, owning up the theme from the introductory line “I know, I Know, I know, I Know, I know…” shows a deep conviction of the understanding of the victim’s predicament, to an extent of retiring on any hope of changing the mind of victim (Lehman and Young 2- verse 1). The fact that the poem is a piece targeting to pass a farewell message illustrates the author as a concerned person, probably after coming to terms with the predicaments of the victim. As outlined above, the author employs two important artistic features that facilitate the presentation of the poem as a complete piece against the choice of its size and design.
Firstly, the precision adopted in the poem manifests through the economy of words, without compromising on the delivery of the central theme. In a weighty theme as suicide and other psychological difficulties experienced by the main character, it would perhaps tempt to apply several words to the poem. However, the author employs precision techniques that augur well with the poem leaving no loopholes, as the initial intention would need. As briefly mentioned above, from the poem’s title, Valediction, the image of sad episodes quickly captures the prediction of the central theme. Valediction is a word with a Latin origin depicting parting ways, particularly in a mourning scenario. Despite the fact that a direct cause for the farewell does not immediately emerge from the title of the poem, the essence of the suspense is established. Without precision and accuracy, the author’s few words would not have captured the central theme surrounding the suicide committed by the victim, despite all indications pointing to the advice of holding on since bigger problems linger around but not sufficient to result to killing oneself.
Following the other works by the author, the orientation of his career against a backdrop of sad topics enables to make a prediction of a tragic setting. To capture similarity of sad moments, perhaps from his life encounters, the author spares the audience wordy descriptions by reckoning, “…dark times are just like those dark times…my sad acquaintance, each dark time is…” (Lehman and Young 2- verse 2). To capture hopelessness, the author uses simple expressions such as, “…indistinguishable from the other dark times, yesterday is as relentless as tomorrow.” It emerges that the sadness cycle is not about to end with the occurrence of the particular event captured in the dedicated valediction. Despair that dominates the author’s choice of topics clearly develops from such presentation with astounding precision.
Additionally, simplicity depicted by the author’s choice of words augurs well with the setting and entire presentation. With regard to the author’s bias towards sad pieces, the approach of avoiding controversy in interpretation of words used pays off. The description of the victim’s state of mind precipitating the suicide adopts a reminder of Chekhov’s perspective in order to avoid controversy. By stating that, “…Chekhov wrote that. He meant it as comfort, and I mean it as comfort, too…” illustrates the level of simplicity that the author adopts in presenting the poem. Apart from the clarity with which the ideas project in the poem, the author keeps the vocabulary of the poem at its minimum best.
It is clear that the author intends to pass a message to the victim who finds myopic solace in suicide. Despite the fact that the victim had all reasons to believe in the words of Chekhov, the author employs irony since the words of caution contained in the poem appear late after the suicide. Speaking to the diseased regarding observing a word of caution delivered long after their last breath is also humorous but simple in expression of the main message. By relating to the past difficulties as the author remembers, the theme of suffering projects itself and the author uses that to offer a rare point of warning to suffering persons. In recognition of the weight of the difficulty that the victim could have experience, the repetition of “I know” presents the author as an empathetic party (Lehman and Young 2- verse 1). Desperation leading suicide victims to the vice gets criticism from the author as he adds his voice to Chekhov’s words that “…yours is not the worst of sorrows,” perhaps giving an account of personal suffering to prevent suicidal thoughts (Lehman and Young 2- verse 4). Desperation observed in sad moments around the author’s life however persist in the poem in that he strongly believes that the victim was destined to commit suicide even if the words of the poem were available beforehand. To illustrate this, the author uses the line, “…you killed yourself because your last dark time was the worst…none of my verse could have saved your life,” (Lehman and Young 2- verse 6-7).
In view of the suitability of this poem, it fits highly for recommendation for inclusion on Eng 102 reading list. At a time when several psychological challenges face the young people in the United States and around the developed world, literature should support their decision making regarding personal ability to withstand devastation. Lessons learnt from the highlight of the author’s background illustrate how contemporary devastation can stand in the way of the uninformed mind. Opening up the young minds to the fact of presence of the best advice to avoid negative thoughts would empower the youth to believe that their problems are just not the worst around. Suicide cases continue to offer a headache to families and the apparent reason must be associated with lack of a passionate speaker having past tribulations with similar challenges. In light of the need for education to offer practical solutions to contemporary challenges, it would be appropriate for Eng 102 to highlight the suicide challenge and offer a different perspective as the author does.
In conclusion, the role of modern literature in dealing with contemporary challenges cannot be overemphasized as Alexie demonstrates in his poem. A simplified presentation as prepared by Alexie captures a rare glimpse at a poor suicide victim overwhelmed by thoughts of inadequacy, which would apparently subside with appropriate information (Mathews para.3). The most dominant concept in the poem against the backdrop of the author’s biography is the practicality of one’s life experiences to withstand sad moments. By giving an authoritative lecture to the diseased, the author directs his advice to potential suicide victims to weather away negative thoughts.
Works Cited
Johansen, Bruce. Native Americans today: a biographical dictionary, Santa Barbara, CA: Greenwood Press, 2010, Print
Lehman, David. & Young, Kevin. The best American poetry 2011, New York, NY: Scribner Poetry, 2012, Print
Mathews, William. “Valediction- Sherman Alexie,” 2012, Web. (19 June 2012) http://blog.passiontask.com/entry/bap12-2-valediction-sherman-alexie/
Vaccinia Virus as an Oncolytic Agent
Vaccinia Virus as an Oncolytic Agent
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Vaccinia Virus as an Oncolytic Agent
The adverse instances of poor pancreatic cancer diagnosis during its treatment prompts the necessity of intervention seeking for more efficacy in therapeutic techniques. Recently, the oncolytic viruses have emerged to promising in the treatment of cancer for the reason that they have the capability of inducing antitumor effects by multiple action mechanism and also can aim and lyse the cancer cells particularly. Vaccinia virus is one of the most prominent oncolytic agents as it comprises a variety of characteristics effective in terminating the tumor cells in human body. Physicians have been working every day to test if efficacy in dealing with fatal pancreatic cancer that emerges among the leading top five cancer killer ailments. In this discussion, vaccinia virus will be discussed to a profound extent in consideration of its potentiality in the controlling pancreatic cancer menace with regards to the standard immunological and cellular mechanisms in the complaint progression.
Pancreatic cancer has remained a deadly disease in the whole world where complete surgical operation persists the only therapeutic diagnosis. For instance, in the United Kingdom, only five percent of the patient affected with this type of cancer survive the early 1970s. However, it is disgusting to learn that not all types of pancreatic cancer are treatable by the complete surgical process as only about twenty of the disease can be controlled through this process. In consideration of other available treatment procedures, chemotherapy means appears to be then dependable and existing medication for treating pancreatic tumor making the affected person have a live expectancy of six months (Potts, et al. 2017). The act of physicians is trying to increase its effectiveness in curing cancer by adding to it absolute proportionate 5-fluorouracil yields a mere change. It increases the patient’s lifespan with a margin of about one-half half month. Therefore, it depicts that more efficient treatment procedures are relevant and fundamental in preventing further demise as well as having a strong medication in future.
Obliteration of smallpox commonly caused by variola virus by the use of Vaccinia virus is among the monumental and most significant achievement in the traditional medicine line. After the medical doctors realizing it importance back then, they have carried out several experiments in determining its extensive use in curing other diseases. These other infections that have been treated by the use of Vaccinia virus apart from tumor and smallpox include tuberculosis, HIV, malaria, immunotherapies, and influenza. There before, it was discouraging to understand that the scientific analysis has postulated that toxicity could be inherent in combining Vaccinia virus with other elements thus could not be applied in treating the tumor. However, after a wide variety of research and medical tests in the recent days, it has been revealed that the Vaccinia virus has the capability of spreading in the cancer matter and lysing the tumor (Moon & Kirn, 2007).The advanced study and knowledge in the sectors of tumor cell biology as well as molecular virology have played a significant role in the establishment of more dependable oncolytic Vaccinia virus to treat pancreatic cancer.
Generally, oncolytic viruses exceedingly fame as anticancer in the modern society have provided light in medication efficiency as well evoking the interests of dealing with the advanced tumor. In effacing the cancer cell, the oncolytic cells targeted on specific tumor follows a particular path in the cancer cell. Oncolytic viruses work by infecting and replicate in the tumor cell leading to cell lysis and the releases of the toxic substance found in the cell. The released viral particles will significantly affect the surrounding cells while the healthy ones free from tumor prevents virus replication through the cellular defense process. In killing the tumor cells, the oncolytic cells applies two mechanisms. The first process is the one illustrated above where the anticancer directly poison, duplicates, and lysis the cancer cells leaving the healthy body cells. The viral component released by the raptured tumor cells contaminates the neighboring infected cells sparing the healthy ones, and the process continues up to the eradication the entire targeted tumor in the body. The second method involves the oncolytic viruses induces pathogen and death related patterns which are released from the immunogenic cells known to cause death. It also depends on the deviation of the immune reaction towards a cytotoxic outline as the infection leads to the release of chemokines and cytokine.
Its auspicious characteristics instigate the capability of Vaccinia virus terminating tumor cells. Being one of the poxvirus family members, Vaccinia virus is composed of a double-stranded deoxyribonucleic acid virus. Considering its structure, a considerable portion is made of deoxyribonucleic acid as well as some viral enzymes which include polyA and ribonucleic acid polymerase whose outer part is covered by a double lipid membrane. Apart from the intracellular mature infectious mechanism describe above regarding the rapture of a tumor cell, Vaccinia virus has another infective process where extracellular covered virion is transferred through membrane fusion (Kirn, et al. 2018). Having a short lifecycle of around eight hours if a desirable feature that plays a vital role in preventing genome integration through cytoplasm elimination. The replication begins about two hours later after the contagion; Vaccinia virus cell rapture takes place between twelve to forty-eight hours releasing the present viral substances.
Also, the Vaccinia virus is less susceptible to the mechanical changes of the affected cell as its mRNA transcription is independent of the host’s biological processes. Furthermore, it is possible for the Vaccinia virus to be dispersed making them not affected while in the bloodstream, hence capable of reaching distance cancer enhancing active infection of the virus. The methodology is significantly useful in treating pancreatic cancer at the advanced level. Its hypoxic conditions also stimulate the management resilient and aggressive physical composition of the pancreatic tumor. It is evident that the hypoxic nature does not have any effect on the cytotoxicity, duplication as well as viral particle production of the Vaccinia virus. The other distinctive characteristic of Vaccinia virus is that it has a good history line as a safe vaccine which has been used over the past century with no any critical negative repercussions.
In recent years, there has been significant attentiveness in Vaccinia virus in the medication field. The reasons behind its interest in treating cancer regard amenability to genetic modification, cancer tropism, safety as well as its capability of reaching various solid target cancer over a distant (Heo, et al. 2013). However, being a new therapeutic medical mechanism Vaccinia virus has to overcome all the challenges as well as other steeplechases before its entry to the formal clinical application. For advancement in Vaccinia virus genetic composition might be the pathway to its excellence as an oncolytic virus competent in treating the pancreatic tumor. It is challenging to determine the right Vaccinia virus strain be used in cancer treatment. Vaccinia virus replication is hindered by the disruption of the null allele genes in the brain which is significant in curbing the encephalitis which is an awkward condition. Furthermore, the combination of Vaccinia virus with the local treatment techniques to a profound extent leads close intervention regarding Vaccinia virus application in dealing with the devastating illness.
In consideration of the discussion above, the pancreatic tumor is one of the deadly and widespread disorder in the world with no effective cure. However, Vaccinia virus has been a promising oncolytic agent that physicians believe will significantly be necessary as well as a practical treatment method. Vaccinia virus is an excellent example of the cancer-targeted oncolytic virus that has ideal and distinctive features that to an in-depth extent fits the treatment of pancreatic cancer. Modifying the viral genes as well as equipping the Vaccinia virus with healing genes is essential in improving the workability of virus in treating the menace (Chard, et al. 2015). Efficacy of Vaccinia virus in curbing pancreatic cancer can also be developed through the process of combining it with other cancer medications whether the chemotherapy of traditional method. With government intervention and exceedingly support towards the medications field can be vital in the establishment of Vaccinia virus as the current and sound treatment to pancreatic tumor. It devastating to understand that this kind of cancer results to demise of high number of people in the universe, with around three percent life expectancy of the infected patients. The trials as well as research done by the physician will at the long-run yield sound solution that will enable the adoption of Vaccinia virus as the major pancreatic cancer treatment vaccine.
References
Chard, L. S., Maniati, E., Wang, P., Zhang, Z., Gao, D., Wang, J., … & Wang, S. (2015). A vaccinia virus armed with interleukin-10 is a promising therapeutic agent for treatment of murine pancreatic cancer. Clinical cancer research, 21(2), 405-416.
Heo, J., Reid, T., Ruo, L., Breitbach, C. J., Rose, S., Bloomston, M., … & Burke, J. (2013). Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer. Nature medicine, 19(3), 329.
Kirn, D., Bell, J., Breitbach, C., Moon, A., Hwang, T. H., Lee, Y. K., & Kim, M. K. (2018). U.S. Patent No. 9,919,047. Washington, DC: U.S. Patent and Trademark Office.
Moon Crompton, A., & Kirn, D. H. (2007). From ONYX-015 to armed vaccinia viruses: the education and evolution of oncolytic virus development. Current cancer drug targets, 7(2), 133-139.
Potts, K. G., Irwin, C. R., Favis, N. A., Pink, D. B., Vincent, K. M., Lewis, J. D., … & Evans, D. H. (2017). Deletion of F4L (ribonucleotide reductase) in vaccinia virus produces a selective oncolytic virus and promotes anti‐tumor immunity with superior safety in bladder cancer models. EMBO molecular medicine, 9(5), 638-654.
Utilization of Artificial Intelligence for Healthcare
Utilization of Artificial Intelligence for Healthcare
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Utilization of Artificial Intelligence for Healthcare
Artificial Intelligence (AI) is the new technological invention that has revolutionized many sectors including the health sector. In recent years, AI tools have been applied in the provision of healthcare. The use of AI tools in healthcare has had several impacts not only on the health sector but also the economy of countries where the technology has been applied. Several healthcare systems have adopted the use of AI technologies both in diagnosis and in the provision of health services. Although the United States has also adopted AI tools into its healthcare system, notable gains are yet to be realized as compared to the impacts that AI technologies have had in other developed countries. This paper presents a report on the utilization of Artificial Intelligence for healthcare in American and potential impacts for economic growth in the country with reference to the use of AI in different countries.
One of the countries with the largest healthcare systems is China. As a developed country, China has often been compared to the United States in various aspects including its healthcare system and economy. China is one of the countries that has adopted the use of Artificial Intelligence in its healthcare system. Through the use of AI technologies, the country has been able to achieve tremendous successes in diagnosis, treatment and post-discharge follow up on patients. One of the notable AI technologies that is widely used in China is the ZhongAnTech technology (Zhang, 2018). The technology enables patients and people seeking health services to interact with physicians, doctors and nurses by allowing them to communicate their needs and facilitating health professionals to provide health services without necessarily seeing their patients physically.
Some of the impacts on healthcare that have been noted in countries that have adopted the use of Artificial Intelligence include; reducing premium rates, ease of access to care, reducing severity of emergency cases, better care for patients with chronic conditions. In Finland where AI has been largely adopted into the provision of healthcare, recent research indicates reduced premium rates among patients. For example, in Finland every year, there are 14,000 people who experience a brain injury that have benefited from the use of AI tools in providing care for them (Dutt, 2020). Due the use of AI in the country, healthcare operations and activities have been made convenient and easier to access.
Besides, cases of deaths associated with chronic conditions have dropped significantly since Artificial Intelligence tools were introduced into Finland’s healthcare system in the 1950s. This is due to the fact that AI tools have come in handy in facilitating follow-up programs for patients with chronic conditions hence reducing avoidable deaths that could result from lack of post-discharge care (Ahmad & Nabi, 2021). Moreover, government spending on healthcare has been significantly reduced since AI tools were adopted in the country’s healthcare system in the 1950s. While it was costly to adopt AI technologies into the healthcare sector at the beginning, the technologies have made provision of healthcare cheaper and cost-effective. This has had an impact in the country’s economy has the country has been able to cut off its expenditure on medications and treatment and labor costs (Zhang, 2018). Besides, money which would have otherwise been used for medication and treatment of its patients have been channeled to other sectors of the economy. This explains why the Finish economy has been stable and on a steady rise since mid-20th century.
Through the storage of large volumes of data that has been made possible by Artificial Intelligence tools such as apps like Babylon used in the UK, medical personnel are able to monitor and account for patient’s medical history thus improving healthcare outcomes. It is undeniable the role that Artificial Intelligence plays in behavioral and mental healthcare in developed countries such as the United Kingdom (Dutt, 2020). AL tools have been designed and developed to work like human brains. AL technologies such as Babylon are equipped to store data which can be used to improve health outcomes. Using data stored in AI tools, the country’s healthcare system has been able to achieve better health outcomes. Data from AI technologies can be used to prescribe medication and treatment to patients based on their medical history.
While the use of Artificial Intelligence makes the provision of health care less costly, it is costly to use traditional methods of healthcare provision. In less developed and developing countries especially in Sub-Saharan Africa, lack of use of Artificial Intelligence is associated with poor health outcomes. In Libya, a country in North Africa, the healthcare system is struggling to meet the needs of its population (Zhang, 2018). Due to the civil war being experienced in the country, there is a high demand of emergency health services. A study conducted in the country in 2019 reveals that about one million people in Libya have acute health needs (Hlávka, 2020). Unfortunately, the healthcare system in the country cannot meet these needs. Due to lack of Artificial Intelligence, the healthcare system in the country is facing a crisis with the demand for health services higher than the ability of the system to provide for these services. Due to the civil war in the country, many healthcare institutions have been destroyed. Moreover, the war has led to an economic crisis in the country hence the government is not able to fund its healthcare system or deploy the use AI tools in its healthcare system.
Similarly, Lebanon is one of the countries in Middle East whose healthcare system is struggling to meet the needs of its ballooning population. Like Libya, Lebanon’s healthcare system is underfunded partly due to the civil conflict being experienced in the country and due to an economic crisis caused by the conflict. As a result, only 8% percent of the population in Lebanon can access health services in public health facilities (Yadav & Mamilla, 2021). On the other hand, the total expenditure on healthcare in the country as of 2019 was 10.6 % of its GDP. As a result of the conflict being experienced in the country, the government cannot fund its healthcare sufficiently. Chronic conditions such as diabetes and hypertension are the leading causes of death in Lebanon (Hlávka, 2020). If the country could afford to adopt Artificial Intelligence into its healthcare system, these deaths could be reduced (Ahmad & Nabi, 2021). Most of the deaths are caused by patients with the pre-existing conditions lacking access to medication and treatment to suppress the effects of these conditions and prevent avoidable deaths. Unfortunately, due to the economic situation in the country, the healthcare system cannot afford to use AI tools to provide care to its population (Yadav & Mamilla, 2021). Besides there is limited workforce to provide health services in health institutions in the country. Artificial Intelligence tools could have been used to substitute the human labor had the country’s economy been stable and if the country could afford to fund AI projects in its healthcare system.
In a nutshell, it is evident that Artificial Intelligence has diverse impacts on both healthcare and the economy of a country. While it enables the provision of better healthcare services, it could be costly to adopt and maintain especially in less developed and developing countries. However, for developed countries such as the United States, Artificial Intelligence can be successful in not only aiding the country improve health outcomes but also develop its economy through export of health services.
References
Ahmad, L., & Nabi, F. (2021). Social and economic impacts. Agriculture 5.0: Artificial Intelligence, IoT, and Machine Learning, 205-213. https://doi.org/10.1201/9781003125433-10Dutt, R. (2020). The impact of artificial intelligence on healthcare insurances. Artificial Intelligence in Healthcare, 271-293. https://doi.org/10.1016/b978-0-12-818438-7.00011-3Hlávka, J. P. (2020). Security, privacy, and information-sharing aspects of healthcare artificial intelligence. Artificial Intelligence in Healthcare, 235-270. https://doi.org/10.1016/b978-0-12-818438-7.00010-1Yadav, A. K., & Mamilla, R. (2021). Artificial intelligence in healthcare. Artificial Intelligence and Global Society, 95-101. https://doi.org/10.1201/9781003006602-9Zhang, Z. (2018). Utilization of electronic healthcare records for advancement of medical knowledge. Journal of Medical Artificial Intelligence, 1, 1-1. https://doi.org/10.21037/jmai.2018.08.01
