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Annotated Literature Review (3)

Mireya Ibanez

March 7, 2021

BME 295C

Ms. Barton

Annotated Literature Review:

1. Mesenchymal Stem Cells in the Treatment of Traumatic Brain Injury.Hasan A, Deeb G, Rahal R, Atwi K, Mondello S, Marei HE, Gali A, Sleiman E.

Front Neurol. 2017 Feb 20;8:28. doi: 10.3389/fneur.2017.00028. eCollection 2017.

PMID: 28265255 

The review introduces the use of the Mesenchymal stem cells in Traumatic Brain injury. Studies have shown that using a MSC approach can be a treatment to patients who have a TBI. One study conducted by Cox involved implanting Mesenchymal stem cells into 10 children. The results showed improvement for 7, and no significant result on the remaining children. The most effective result reoccurred the sooner the patient received the Mesenchymal stem cells. MSC is growing to be an enormous opportunity for helping people post- TBI repair.

2. Potential of mesenchymal stem cells alone, or in combination, to treat traumatic brain injury.Willing AE, Das M, Howell M, Mohapatra SS, Mohapatra S.

CNS Neurosci Ther. 2020 Jun;26(6):616-627. doi: 10.1111/cns.13300. Epub 2020 Mar 10.

PMID: 32157822 

Mesenchymal stem cell therapy has been showing promising results in ongoing clinical studies. There is different therapeutic approaches for a Traumatic Brain Injury in combination with clinical Mesenchymal stem cell trials. The clinical trials have at least entered the beginning stages (safety phases) for multiple diseases and injuries including TBI’s. Researchers have been able to get a better understanding of what occurs to the body after sustaining a TBI and how Mesenchymal stem cells repairs the brain and improves functional outcomes. A lot of research and clinical trials is still needed to be able to create an effective therapy for patients suffering from Traumatic Brain injury.

3. Systemic administration of cell-free exosomes generated by human bone marrow derived mesenchymal stem cells cultured under 2D and 3D conditions improves functional recovery in rats after traumatic brain injury.Zhang Y, Chopp M, Zhang ZG, Katakowski M, Xin H, Qu C, Ali M, Mahmood A, Xiong Y.

Neurochem Int. 2017 Dec;111:69-81. doi: 10.1016/j.neuint.2016.08.003. Epub 2016 Aug 15.

PMID: 27539657 

A study has been conducted to see if the administration of cell-free exosomes derived from h-Mesenchymal stem cells can promote functional recovery and neurovascular remodeling in rats after a Traumatic Brain injury. Wistar rats were tested by giving them an induced TBI and 24 hours later injecting them with the exosomes. The exosomes treatment significantly improved functional recovery in rats after obtaining a Traumatic Brain injury. The results included promoting endogenous angiogenesis and neurogenesis and reducing inflammation. hMSCs have the potential to be a cell-free therapy for a TBI and exosomes can possibly enhance spatial learning.

4. Human adipose-derived mesenchymal stem cells for acute and sub-acute TBI.Ruppert KA, Prabhakara KS, Toledano-Furman NE, Udtha S, Arceneaux AQ, Park H, Dao A, Cox CS, Olson SD.

PLoS One. 2020 May 26;15(5):e0233263. doi: 10.1371/journal.pone.0233263. eCollection 2020.

PMID: 32453741 

There are many attempts of intervention focusing on protection and, repair or regeneration when traumatic brain injury occurs. The use of stem cells from a variety of sources and applications has been studied in many disease and injury models. This study involves administering h-Mesenchymal stem cells into a rat. The earliest administration at 3 days after and delayed administration 14 days after a controlled cortical impact injury. The treatments show improvements in neurocognitive outcome and a change in the neuroinflammation one month after the injury. There is significant data and results that support the idea of using adMSC to treat a TBI. There is still ongoing research to find the optimal time to administrate the therapy to have the most successful results.

5. Bone marrow mesenchymal stem cells combined with Sox2 increase the functional recovery in rat with traumatic brain injury.Hao Q, Zheng J, Hu Y, Wang H.

Chin Neurosurg J. 2019 May 15;5:11. doi: 10.1186/s41016-019-0158-7. eCollection 2019.

PMID: 32922911 

In many studies, it is found that the stem cell transplantation holds potential results for modifying motor dysfunctions caused by Traumatic Brain injuries. 26 rats were used in a study, with 2 rats being bone marrow stem cell donors. 2 days after a Traumatic Brain injury, the rats were induced with SOX-2 and the study examined the effects of SOX-2 with the differentiation of bsMSCs. The motor function was tested using NSS. (Neurological severity score) The study showed there was neurological function improvements. This treatment is another step to creating a promising therapy for Traumatic Brain Injuries.

6. Transplantation of R-GSIK scaffold with mesenchymal stem cells improves neuroinflammation in a traumatic brain injury model.Sahab Negah S, Shirzad MM, Biglari G, Naseri F, Hosseini Ravandi H, Hassani Dooghabadi A, Gorji A.

Cell Tissue Res. 2020 Dec;382(3):575-583. doi: 10.1007/s00441-020-03247-0. Epub 2020 Jul 27.

PMID: 32715374 

Neural tissue engineering has been introduced by using Mesenchymal stem cells and R-GSIK to provide a therapeutic strategy for a Traumatic Brain injury. The study was designed to promote the behavior of the stem cells by incorporating R-GSIK in rats. There was significant recovery of motor function observed in the rats that received Mesenchymal stem cells and R-GSIK. Compared to other control groups there was a reduction in pro-inflammatory cytokines. This helped to strengthen the idea that R-GSIK and Mesenchymal stem cells are a step in helping patients who suffer from a Traumatic Brain injury.

7. Transplantation of mesenchymal stem cells genetically engineered to overexpress interleukin-10 promotes alternative inflammatory response in rat model of traumatic brain injury.Peruzzaro ST, Andrews MMM, Al-Gharaibeh A, Pupiec O, Resk M, Story D, Maiti P, Rossignol J, Dunbar GL.

J Neuroinflammation. 2019 Jan 5;16(1):2. doi: 10.1186/s12974-018-1383-2.

PMID: 30611291 

Traumatic Brain injury are major causes to long term disability with a limit on the treatments available. In order to see responses of the methods, researchers look at the Neuroinflammatory responses. One specific method involves transplantation of Mesenchymal stem cells. These Mesenchymal stem cells release trophic and pro-repair cytokine, specifically interleukin10. The study tests the therapeutic effects when transplanted into rats that endured a Traumatic brain injury in the frontal cortex. There were significant improvements to reduce inflammation and promote functional outcomes, although further testing and research needs to be conducted. This could be very good in human research, if the rats continue to show good results.

8. Treating childhood traumatic brain injury with autologous stem cell therapy.Dewan S, Schimmel S, Borlongan CV.

Expert Opin Biol Ther. 2018 May;18(5):515-524. doi: 10.1080/14712598.2018.1439473. Epub 2018 Feb 15.

PMID: 29421958 

A significant contributor to developmental disorders occurs from childhood related Traumatic Brain Injuries. Stem cell therapy, meaning using stem cells from the own individual is a believed therapy to enhance the repair of the injured neonatal brain. The use of autologous stem cells can delay ad possibly stop the neuroinflammation that causes cell death to occur. This therapy has very promising potential to treating neuroinflammation related with acute and progressive stages of neonatal Traumatic brain injury. There is a bunch of room of new information that can help the therapy, such as introducing new components to ensure a good outcome.

English- Case Study

Case Study

(Author’s name)

(Institutional Affiliation)

Current Performance

To understand the activities this case study is about to undertake, one needs to have a clear understanding of the student under evaluation, as well as, the methods and procedures for assisting this student in dealing with his problem. Throughout the study, the student in question shall be referred to as X, as a way of hiding their true identity.

Abilities and Support Needs

The student under study is an 8-year-old female who is currently suffering from dyslexia. She attends a public school and because of her ailment, is forced to spend 50% of her school day in self-containment. Her teachers have decided to put her under self-containment because she is a slow learner, and for that reason, cannot study in the same classroom as her fellow classmates. As her teachers explain, she has a developmental reading disorder that affects the normal learning process for her. This disorder has affected the student so much that she has developed additional behavioral problems, to her inability to progress in her education (Bradford, 2009). Her performance has been stagnant from her first exposure to learning, illustrating that she is not meeting her educational goals as expected.

Past Experiences

Based on the information provided by her teachers and educators, we are made to understand that her problem was first recognized in her first class, and she could not engage in simple learning activities like her fellow students. She has a problem with reading, and has trouble recognizing written words. She also has trouble engaging in simple rhyming activities that are part of the learning process for children her age, and cannot make meaning and ideas of simple sentences. This has, in turn, affected her overall learning experience and outcome, especially in language and linguistics.

IEP Appropriateness

Having established that student X is a special needs student, there is need to develop an individualized education program (IEP) to assist this student in achieving their educational goals. Because student X suffers from dyslexia, the IEP will facilitate the attainment of the student’s educational goals much faster than she otherwise could.

Goals and Objectives

The goals and objectives of this IEP case include:

To ensure that student X meets her educational goals by the end of the year. This will be evaluated through the performance of other students in her class.

To dissuade the behavioral problems that student X experiences and improve the social skills of student X.

To ensure an improvement of perpetual skills in student X, allowing the student to read and understand what she is taught in class.

To train Student X’s educator on the different instructional methods that they can use to help student X attain her educational goals and objectives.

To restructure the regular class curriculum so that it accommodates student X, allowing the student to mix with the others, hence building on her social skills.

Educational Standards

The goals and objectives of this IEP are also aimed at improving the educational standards of the school where student X studies (Bradford, 2009). The relation between the goals and the standards is both theoretical and practical. Theoretically, the goals and objectives will assist both the student and her educator in reaching their individual, set standards for education.

Environmental Demands

To, successfully, implement this IEP case, there are various environmental demands that need to be met, in relation to the classroom setting and the activities to be carried out during this process.

Classroom Arrangement

The classroom arrangement in any IEP case is very crucial for the success of the program. It is through a proper classroom arrangement, that the instructor can effectively, and efficiently, teach student X to ensure educational success. Student X needs to be placed in a classroom that is not too congested and not too spacious to distract the student during learning. Additionally, the arrangement will be in such a way that facilitates group-learning activities such as reading and spelling (Bradford, 2009). This will assist student X in improving their social skills, as well as, reduce her behavioral problems. She will also be allowed to seat at the front of the class so that her instructor always keeps an eye on her during lessons. Large alphabetical writings and other language writings will be hanged around the class so as to familiarize the student with the alphabet and decrease the possibility of memory loss in student X.

Activities Schedule

Because student X has a learning disability, the activities taking place will not be any different from the normal activities in the classroom. This is because, the aim here is to help X reach the same educational level as the rest of her classmate, and because we do not wish to slow the learning process of the rest of the students down. The main activities will include spelling tests, rhyming, reading, and writing (Bradford, 2009). Reading will be done both as group work and as an individual activity, the instructor will be part of these activities as he shall act as a guide for these activities.

Environmental Challenges

Because student X is a special needs student, there are a number of obvious challenges that she will face during this process. For example, she will need to adapt to being around others, as well as, reading out loud without feeling embarrassed.

Task and Instructional Demands

As mentioned earlier, the instructor will play a role in the activities that are scheduled to take place during the IEP plan. The instructor will guide student X all through the learning process so as to ensure that they both reach their educational goals.

Required Typical Tasks

Student X will be required to carry out a number of tasks such as verbal spelling, reading aloud, rhyming, writing, repeating after the teacher, and engaging other students in activities and games (Bradford, 2009).

Appropriateness of Tasks

These tasks are appropriate for the student, as they will assist her in overcoming her learning problem and disability. More specifically these tasks are aimed at assisting student X in comprehending words and their meanings especially in sentences (Bradford, 2009). This, in turn, improves her comprehension and awareness.

Student Directions

Directions will be given to student X in the most basic manner, i.e., the student will be asked to perform a particular activity as per the learning guideline. Avoiding complex instructions is necessary for communication purposes especially since student X suffers from dyslexia (Bradford, 2009). It will assist the educator to know whether student X understands what she is being directed to do.

Teaching Strategies

The three main teaching strategies that will be used for student X include remedial instruction, private tutoring, and the provision of special day classes (Bradford, 2009). This will assist in meeting the needs of the student as it will allow the student to meet their educational objectives with ease.

Functional Behavioral Assessment

Functional behavioral assessment (FBA) is a procedure that is carried out to determine the reasons behind a person’s behavior (Bradford, 2009). FBA is necessary when dealing with students with special needs but in this particular case it is not necessary as student X does not display major behavioral problems. She is shy and appears intimidated, and this prevents her from socializing with her fellow classmates. The focus of this study is to assist student X overcome her learning problem, thus an FBA is not required for student X.

Supports Modifications and Accommodations

For the program to take full effect, there is need for the provision of supports by the various parties included. Modifications also need to be made so as to come up with the best strategies, as well as the provision of accommodation for the various activities.

Functional Academics

To assess the curriculum presented to student X the student may need special assistance, which may be provided by her instructor, parents, or other outside parties. Student X will need psychological services, health services, recreational services, as well as, speech-language pathology services (Bradford, 2009).

Behavioral

The behavioral supports and modifications that student X will need are primarily based on increasing her self-esteem and giving her confidence in her educational and social activities.

Social Outcomes

Essentially the social outcomes expected from her education placement is that student X will become more social with her classmates. This will also allow her to improve on her learning so as to effectively socialize with her friends.

Program Evaluation

Having established the problems that need to be addressed when dealing with student X as a special needs child, there is need for a program evaluation to determine whether the program is appropriate for the child.

Evaluation Method

Placement will be evaluated according to the ability to meet the needs of student X accordingly. The program that managed to achieve this with minimal interference will be chosen as the best suited program for student X.

Responsible Parties

There will be specific duties during this program, which will be carried out by different people. These people include the instructor, Student X’s parents, as well as, the student’s therapist.

References

Bradford, J. (2009). Dyslexia Parents Resource: IEPs and the IDEA. Retrieved from:

http://www.dyslexia-parent.com/IDEA.html

Annotated Literature Review (2)

Mireya Ibanez

March 7, 2021

BME 295C

Ms. Barton

Annotated Literature Review:

1. Mesenchymal Stem Cells in the Treatment of Traumatic Brain Injury.Hasan A, Deeb G, Rahal R, Atwi K, Mondello S, Marei HE, Gali A, Sleiman E.

Front Neurol. 2017 Feb 20;8:28. doi: 10.3389/fneur.2017.00028. eCollection 2017.

PMID: 28265255 

The review introduces the use of the Mesenchymal stem cells in Traumatic Brain injury. Studies have shown that using a MSC approach can be a treatment to patients who have a TBI. One study conducted by Cox involved implanting Mesenchymal stem cells into 10 children. The results showed improvement for 7, and no significant result on the remaining children. The most effective result reoccurred the sooner the patient received the Mesenchymal stem cells. MSC is growing to be an enormous opportunity for helping people post- TBI repair.

2. Potential of mesenchymal stem cells alone, or in combination, to treat traumatic brain injury.Willing AE, Das M, Howell M, Mohapatra SS, Mohapatra S.

CNS Neurosci Ther. 2020 Jun;26(6):616-627. doi: 10.1111/cns.13300. Epub 2020 Mar 10.

PMID: 32157822 

Mesenchymal stem cell therapy has been showing promising results in ongoing clinical studies. There is different therapeutic approaches for a Traumatic Brain Injury in combination with clinical Mesenchymal stem cell trials. The clinical trials have at least entered the beginning stages (safety phases) for multiple diseases and injuries including TBI’s. Researchers have been able to get a better understanding of what occurs to the body after sustaining a TBI and how Mesenchymal stem cells repairs the brain and improves functional outcomes. A lot of research and clinical trials is still needed to be able to create an effective therapy for patients suffering from Traumatic Brain injury.

3. Systemic administration of cell-free exosomes generated by human bone marrow derived mesenchymal stem cells cultured under 2D and 3D conditions improves functional recovery in rats after traumatic brain injury.Zhang Y, Chopp M, Zhang ZG, Katakowski M, Xin H, Qu C, Ali M, Mahmood A, Xiong Y.

Neurochem Int. 2017 Dec;111:69-81. doi: 10.1016/j.neuint.2016.08.003. Epub 2016 Aug 15.

PMID: 27539657 

A study has been conducted to see if the administration of cell-free exosomes derived from h-Mesenchymal stem cells can promote functional recovery and neurovascular remodeling in rats after a Traumatic Brain injury. Wistar rats were tested by giving them an induced TBI and 24 hours later injecting them with the exosomes. The exosomes treatment significantly improved functional recovery in rats after obtaining a Traumatic Brain injury. The results included promoting endogenous angiogenesis and neurogenesis and reducing inflammation. hMSCs have the potential to be a cell-free therapy for a TBI and exosomes can possibly enhance spatial learning.

4. Human adipose-derived mesenchymal stem cells for acute and sub-acute TBI.Ruppert KA, Prabhakara KS, Toledano-Furman NE, Udtha S, Arceneaux AQ, Park H, Dao A, Cox CS, Olson SD.

PLoS One. 2020 May 26;15(5):e0233263. doi: 10.1371/journal.pone.0233263. eCollection 2020.

PMID: 32453741 

There are many attempts of intervention focusing on protection and, repair or regeneration when traumatic brain injury occurs. The use of stem cells from a variety of sources and applications has been studied in many disease and injury models. This study involves administering h-Mesenchymal stem cells into a rat. The earliest administration at 3 days after and delayed administration 14 days after a controlled cortical impact injury. The treatments show improvements in neurocognitive outcome and a change in the neuroinflammation one month after the injury. There is significant data and results that support the idea of using adMSC to treat a TBI. There is still ongoing research to find the optimal time to administrate the therapy to have the most successful results.

5. Bone marrow mesenchymal stem cells combined with Sox2 increase the functional recovery in rat with traumatic brain injury.Hao Q, Zheng J, Hu Y, Wang H.

Chin Neurosurg J. 2019 May 15;5:11. doi: 10.1186/s41016-019-0158-7. eCollection 2019.

PMID: 32922911 

In many studies, it is found that the stem cell transplantation holds potential results for modifying motor dysfunctions caused by Traumatic Brain injuries. 26 rats were used in a study, with 2 rats being bone marrow stem cell donors. 2 days after a Traumatic Brain injury, the rats were induced with SOX-2 and the study examined the effects of SOX-2 with the differentiation of bsMSCs. The motor function was tested using NSS. (Neurological severity score) The study showed there was neurological function improvements. This treatment is another step to creating a promising therapy for Traumatic Brain Injuries.

6. Transplantation of R-GSIK scaffold with mesenchymal stem cells improves neuroinflammation in a traumatic brain injury model.Sahab Negah S, Shirzad MM, Biglari G, Naseri F, Hosseini Ravandi H, Hassani Dooghabadi A, Gorji A.

Cell Tissue Res. 2020 Dec;382(3):575-583. doi: 10.1007/s00441-020-03247-0. Epub 2020 Jul 27.

PMID: 32715374 

Neural tissue engineering has been introduced by using Mesenchymal stem cells and R-GSIK to provide a therapeutic strategy for a Traumatic Brain injury. The study was designed to promote the behavior of the stem cells by incorporating R-GSIK in rats. There was significant recovery of motor function observed in the rats that received Mesenchymal stem cells and R-GSIK. Compared to other control groups there was a reduction in pro-inflammatory cytokines. This helped to strengthen the idea that R-GSIK and Mesenchymal stem cells are a step in helping patients who suffer from a Traumatic Brain injury.

7. Transplantation of mesenchymal stem cells genetically engineered to overexpress interleukin-10 promotes alternative inflammatory response in rat model of traumatic brain injury.Peruzzaro ST, Andrews MMM, Al-Gharaibeh A, Pupiec O, Resk M, Story D, Maiti P, Rossignol J, Dunbar GL.

J Neuroinflammation. 2019 Jan 5;16(1):2. doi: 10.1186/s12974-018-1383-2.

PMID: 30611291 

Traumatic Brain injury are major causes to long term disability with a limit on the treatments available. In order to see responses of the methods, researchers look at the Neuroinflammatory responses. One specific method involves transplantation of Mesenchymal stem cells. These Mesenchymal stem cells release trophic and pro-repair cytokine, specifically interleukin10. The study tests the therapeutic effects when transplanted into rats that endured a Traumatic brain injury in the frontal cortex. There were significant improvements to reduce inflammation and promote functional outcomes, although further testing and research needs to be conducted. This could be very good in human research, if the rats continue to show good results.

8. Treating childhood traumatic brain injury with autologous stem cell therapy.Dewan S, Schimmel S, Borlongan CV.

Expert Opin Biol Ther. 2018 May;18(5):515-524. doi: 10.1080/14712598.2018.1439473. Epub 2018 Feb 15.

PMID: 29421958 

A significant contributor to developmental disorders occurs from childhood related Traumatic Brain Injuries. Stem cell therapy, meaning using stem cells from the own individual is a believed therapy to enhance the repair of the injured neonatal brain. The use of autologous stem cells can delay ad possibly stop the neuroinflammation that causes cell death to occur. This therapy has very promising potential to treating neuroinflammation related with acute and progressive stages of neonatal Traumatic brain injury. There is a bunch of room of new information that can help the therapy, such as introducing new components to ensure a good outcome.